New generation multi-modal antidepressants: focus on vortioxetine for major depressive disorder

Vortioxetine is a novel antidepressant with effects on multiple 5-HT receptors and on the serotonin transporter. This paper reviews preclinical and clinical evidence regarding its mechanism of action, its tolerability, and its efficacy in treating major depression. Clinical studies indicate that vor...

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Bibliographic Details
Published in:Neuropsychiatric disease and treatment 2014-01, Vol.10, p.349-354
Main Authors: Katona, Cornelius L, Katona, Cara P
Format: Article
Language:English
Subjects:
Antidepressants
Drug dosages
Drug therapy
major depression
Major depressive disorder
Mental depression
Psychiatry
Review
Serotonin
Studies
vortioxetine
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Summary:Vortioxetine is a novel antidepressant with effects on multiple 5-HT receptors and on the serotonin transporter. This paper reviews preclinical and clinical evidence regarding its mechanism of action, its tolerability, and its efficacy in treating major depression. Clinical studies indicate that vortioxetine is effective in the treatment of major depression, though there is no suggestion of superiority over active comparators. There may be a clinically meaningful advantage in terms of tolerability.
ISSN:1176-6328
1176-6328
1178-2021
DOI:10.2147/NDT.S39544