Detection of Retinal Nerve Fiber Layer Defects in Alzheimer's Disease Using SD-OCT

Our aim is to examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer's disease (AD). This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years...

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Bibliographic Details
Published in:Frontiers in psychiatry 2014, Vol.5, p.22-22
Main Authors: Kromer, Robert, Serbecic, Nermin, Hausner, Lucrezia, Froelich, Lutz, Aboul-Enein, Fahmy, Beutelspacher, Sven C
Format: Article
Language:English
Subjects:
Psychiatry
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Summary:Our aim is to examine the clinical value of spectral-domain optical coherence tomography (Spectralis OCT) to detect retinal nerve fibre layer defects in patients with clinically defined Alzheimer's disease (AD). This cross-sectional study included 22 patients with AD (mean age: 75.9 ± 6.1 years) and 22 healthy age- and sex-matched controls. Neuro-ophthalmologic examinations and a series of high-resolution OCT examinations of the peripapillary retinal nerve fiber layer (RNFL) thickness using the Spectralis 3.5-mm circle scan protocol with ART-Modus and eye tracking were obtained, and compared to age- and sex-matched healthy control subjects. Patients with AD showed a significant decrease in RNFL thickness in the nasal superior sector compared to the control group (101.0 ± 18.18 μm versus 122.8 ± 28.08 μm; P 
ISSN:1664-0640
1664-0640
DOI:10.3389/fpsyt.2014.00022