3.0T 31P MR spectroscopy in assessment of response to antiviral therapy for chronic hepatitis C

AIM:To investigate the utility of phosphorus-31(31P)magnetic resonance spectroscopy(MRS)as a noninvasive test for assessment of response to interferon and ribavirin treatment in patients with different severities of hepatitis C virus infection.METHODS:Sixty chronic hepatitis C patients undergoing an...

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Published in:World journal of gastroenterology : WJG 2014-02, Vol.20 (8), p.2107-2112
Main Authors: Zhang, Chun-Yu, Zhang, Qian, Zhang, Hui-Mao, Yang, Hai-Shan
Format: Article
Language:English
Subjects:
31P
Aged
Antiviral Agents - therapeutic use
Brief
Esters - analysis
Female
Hepatitis
Hepatitis C, Chronic - drug therapy
Hepatitis C, Chronic - pathology
Humans
Interferons - therapeutic use
Liver - pathology
Liver Cirrhosis - pathology
Liver Cirrhosis - virology
Magnetic
Magnetic Resonance Spectroscopy
Male
Middle Aged
Phosphorus - analysis
resonance
Ribavirin - therapeutic use
spectroscopy
Time Factors
Treatment Outcome
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Summary:AIM:To investigate the utility of phosphorus-31(31P)magnetic resonance spectroscopy(MRS)as a noninvasive test for assessment of response to interferon and ribavirin treatment in patients with different severities of hepatitis C virus infection.METHODS:Sixty chronic hepatitis C patients undergoing antiviral therapy with interferon and ribavirin underwent 31P MRS at 3.0T before treatment,6 mo after the start of treatment,and 1 year after the start of treatment.RESULTS:The phosphomonoester(PME)/phosphodiester(PDE)ratio at 6 mo after the start of antiviral therapy in the Child-Pugh B and C groups were significantly higher than those before therapy,but this was not seen in the Child-Pugh A group.In the antiviral therapy group,the PME/PDE ratios had decreased on follow-up MR spectroscopy.However,in the virological nonresponder group,the PME/PDE ratios on follow-up imaging were similar to the baseline values.CONCLUSION:31P MRS can be used to provide biochemical information on hepatic metabolic processes.This study indicates that the PME/PDE ratio can be used as an indicator of response to antiviral treatment in chronic hepatitis C patients.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i8.2107