Plasma Apolipoprotein L1 Levels Do Not Correlate with CKD

Polymorphisms in APOL1 are associated with CKD, including HIV-related CKD, in individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is localized in kidney cells, but the contribution of APOL1 location to CKD pathogenesis is unclear. We examined associations of plasma...

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Bibliographic Details
Published in:Journal of the American Society of Nephrology 2014-03, Vol.25 (3), p.634-644
Main Authors: BRUGGEMAN, Leslie A, O'TOOLE, John F, KALAYJIAN, Robert C, ROSS, Michael D, MADHAVAN, Sethu M, SMURZYNSKI, Marlene, KUNLING WU, BOSCH, Ronald J, GUPTA, Samir, POLLAK, Martin R, SEDOR, John R
Format: Article
Language:English
Subjects:
Adult
African Americans - genetics
AIDS-Associated Nephropathy - blood
AIDS-Associated Nephropathy - genetics
Apolipoprotein L1
Apolipoproteins - blood
Apolipoproteins - genetics
Biological and medical sciences
Case-Control Studies
Clinical Research
Cytokines - blood
Disease Progression
Dyslipidemias - blood
Female
Genotype
Glomerular Filtration Rate
Humans
Kidneys
Lipoproteins, HDL - blood
Lipoproteins, HDL - genetics
Longitudinal Studies
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Nephropathies. Renovascular diseases. Renal failure
Phenotype
Randomized Controlled Trials as Topic
Renal failure
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - genetics
Urinary system involvement in other diseases. Miscellaneous
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Description
Summary:Polymorphisms in APOL1 are associated with CKD, including HIV-related CKD, in individuals of African ancestry. The apolipoprotein L1 (APOL1) protein circulates and is localized in kidney cells, but the contribution of APOL1 location to CKD pathogenesis is unclear. We examined associations of plasma APOL1 levels with plasma cytokine levels, dyslipidemia, and APOL1 genotype in a nested case-control study (n=270) of HIV-infected African Americans enrolled in a multicenter prospective observational study. Patients were designated as having CKD when estimated GFR (eGFR) decreased to
ISSN:1046-6673
1533-3450
DOI:10.1681/ASN.2013070700