Molecular mechanisms underlying chronic inflammation-associated cancers

Highlights • Redox-related transcription factor upregulation characterizes inflammation-related cancer. • NADPH oxidase-dependent ROS are associated with inflammation and tumor promotion. • Interdicting ROS-mediated inflammation is a novel cancer prevention strategy.

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Bibliographic Details
Published in:Cancer letters 2014-04, Vol.345 (2), p.164-173
Main Authors: Wu, Yongzhong, Antony, Smitha, Meitzler, Jennifer L, Doroshow, James H
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Anti-Inflammatory Agents - therapeutic use
Antineoplastic Agents - therapeutic use
Apoptosis
Cancer
Cell growth
Cell Transformation, Neoplastic - immunology
Cell Transformation, Neoplastic - metabolism
Chronic Disease
Cytokines
Deoxyribonucleic acid
DNA
DNA damage
Enzymes
Hematology, Oncology and Palliative Medicine
Hepatitis
Humans
Hypoxia
Immune system
Infections
Inflammation
Inflammation - complications
Inflammation - drug therapy
Inflammation - genetics
Inflammation - immunology
Inflammation - metabolism
Inflammation Mediators - metabolism
Inflammatory bowel disease
Kinases
Liver cancer
NADPH oxidase
NADPH Oxidases - metabolism
Neoplasms - drug therapy
Neoplasms - etiology
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - metabolism
Oxidative Stress
Pancreatic cancer
Phosphorylation
Prostate cancer
Proteins
Reactive oxygen
Reactive Oxygen Species - metabolism
Signal Transduction
Stress
Transcription factors
Transcription Factors - metabolism
Tumor Microenvironment
Tumors
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Description
Summary:Highlights • Redox-related transcription factor upregulation characterizes inflammation-related cancer. • NADPH oxidase-dependent ROS are associated with inflammation and tumor promotion. • Interdicting ROS-mediated inflammation is a novel cancer prevention strategy.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.08.014