New developments in clinical aspects of lymphatic disease

The lymphatic system is fundamentally important to cardiovascular disease, infection and immunity, cancer, and probably obesity--the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has de...

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Bibliographic Details
Published in:The Journal of clinical investigation 2014-03, Vol.124 (3), p.915-921
Main Authors: Mortimer, Peter S, Rockson, Stanley G
Format: Article
Language:English
Subjects:
Animals
Autoimmune diseases
Biomarkers
Biomedical research
Cancer
Cancer therapies
Cardiovascular disease
Cellulitis - immunology
Cellulitis - microbiology
Crohn Disease - physiopathology
Development and progression
Genetic aspects
Genetic Predisposition to Disease
Humans
Lymphadenitis - immunology
Lymphadenitis - pathology
Lymphatic Metastasis
Lymphatic system
Lymphatic Vessels - pathology
Lymphatic Vessels - physiopathology
Lymphedema
Lymphedema - diagnosis
Lymphedema - genetics
Lymphedema - immunology
Lymphedema - therapy
Neoplasms - pathology
Obesity - physiopathology
Plasma
Proteins
Review Series
Rodents
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Summary:The lymphatic system is fundamentally important to cardiovascular disease, infection and immunity, cancer, and probably obesity--the four major challenges in healthcare in the 21st century. This Review will consider the manner in which new knowledge of lymphatic genes and molecular mechanisms has demonstrated that lymphatic dysfunction should no longer be considered a passive bystander in disease but rather an active player in many pathological processes and, therefore, a genuine target for future therapeutic developments. The specific roles of the lymphatic system in edema, genetic aspects of primary lymphedema, infection (cellulitis/erysipelas), Crohn's disease, obesity, cancer, and cancer-related lymphedema are highlighted.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI71608