Mitochondria: A kinase anchoring protein 1, a signaling platform for mitochondrial form and function

Mitochondria are best known for their role as cellular power plants, but they also serve as signaling hubs, regulating cellular proliferation, differentiation, and survival. A kinase anchoring protein 1 (AKAP1) is a scaffold protein that recruits protein kinase A (PKA) and other signaling proteins,...

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Bibliographic Details
Published in:The international journal of biochemistry & cell biology 2014-03, Vol.48, p.92-96
Main Authors: Merrill, Ronald A., Strack, Stefan
Format: Article
Language:English
Subjects:
A Kinase Anchor Proteins - metabolism
Anchoring
Animals
Cascades
Cellular
Dynamin-related protein 1
Enzymes
Humans
Kinases
Mitochondria
Mitochondria - metabolism
Mitochondrial Dynamics
Mitochondrial fission
Phosphorylation
Protein kinase A
Protein phosphatases
Proteins
Signal Transduction
Survival
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Summary:Mitochondria are best known for their role as cellular power plants, but they also serve as signaling hubs, regulating cellular proliferation, differentiation, and survival. A kinase anchoring protein 1 (AKAP1) is a scaffold protein that recruits protein kinase A (PKA) and other signaling proteins, as well as RNA, to the outer mitochondrial membrane. AKAP1 thereby integrates several second messenger cascades to modulate mitochondrial function and associated physiological and pathophysiological outcomes. Here, we review what is currently known about AKAP1's macromolecular interactions in health and disease states, including obesity. We also discuss dynamin-related protein 1 (Drp1), the enzyme that catalyzes mitochondrial fission, as one of the key substrates of the PKA/AKAP1 signaling complex in neurons. Recent evidence suggests that AKAP1 has critical roles in neuronal development and survival, which are mediated by inhibitory phosphorylation of Drp1 and maintenance of mitochondrial integrity.
ISSN:1357-2725
1878-5875
DOI:10.1016/j.biocel.2013.12.012