Cardioembolic Stroke Diagnosis Using Blood Biomarkers

Stroke is one of the main causes of death and disability in the world. Cardioembolic etiology accounts for approximately one fifth of all ischemic strokes whereas 25-30% remains undetermined even after an advanced diagnostic workup. Despite there is not any biomarker currently approved to distinguis...

Full description

Saved in:
Bibliographic Details
Published in:Current cardiology reviews 2013-11, Vol.9 (4), p.340-352
Main Authors: Llombart, Victor, Garcia-Berrocoso, Teresa, Bustamante, Alejandro, Fernandez-Cadenas, Israel, Montaner, Joan
Format: Article
Language:English
Subjects:
Biomarkers - blood
Endothelium, Vascular
Gene Expression
Genetic Markers
Humans
Inflammation - blood
MicroRNAs - blood
Polymorphism, Genetic
Stroke - blood
Stroke - classification
Stroke - etiology
Stroke - therapy
Thrombosis - blood
Thrombosis - diagnosis
Thrombosis - etiology
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stroke is one of the main causes of death and disability in the world. Cardioembolic etiology accounts for approximately one fifth of all ischemic strokes whereas 25-30% remains undetermined even after an advanced diagnostic workup. Despite there is not any biomarker currently approved to distinguish cardioembolic stroke among other etiologies in clinical practice the use of biomarkers represents a promising valuable complement to determine stroke etiology reducing the number of cryptogenic strokes and aiding in the prescription of the most appropriated primary and secondary treatments in order to minimize therapeutic risks and to avoid recurrences. In this review we present an update about specific cardioembolic stroke-related biomarkers at a protein, transcriptomic and genetic level. Finally, we also focused on reported biomarkers associated with atrial fibrillation (a cardiac illness strongly related with cardioembolic stroke subtype) thus with a potential to become biomarkers to detect cardioembolic stroke in the future.
ISSN:1573-403X
1875-6557
DOI:10.2174/1573403X10666140214122633