The Influence of an Obesogenic Diet on Oxysterol Metabolism in C57BL/6J Mice

Our current understanding of oxysterol metabolism during different disease states such as obesity and dyslipidemia is limited. Therefore, the aim of this study was to determine the effect of diet-induced obesity on the tissue distribution of various oxysterols and the mRNA expression of key enzymes...

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Bibliographic Details
Published in:Cholesterol 2014-01, Vol.2014 (2014), p.g1-11
Main Authors: Wooten, Joshua S., Wu, Huaizhu, Raya, Joe, Perrard, Xiaoyuan Dai, Gaubatz, John, Hoogeveen, Ron C.
Format: Article
Language:English
Subjects:
Apoptosis
Atherosclerosis
Cholesterol
Cholesterol metabolism
Cytotoxicity
Development and progression
Diabetes
Enzymes
Genetic aspects
Lipids
Medicine
Metabolism
Metabolites
Obesity
Oxidative stress
Physiological aspects
Rodents
Studies
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Summary:Our current understanding of oxysterol metabolism during different disease states such as obesity and dyslipidemia is limited. Therefore, the aim of this study was to determine the effect of diet-induced obesity on the tissue distribution of various oxysterols and the mRNA expression of key enzymes involved in oxysterol metabolism. To induce obesity, male C57BL/6J mice were fed a high fat-cholesterol diet for 24 weeks. Following diet-induced obesity, plasma levels of 4β-hydroxycholesterol, 5,6α-epoxycholesterol, 5,6β-epoxycholesterol, 7α-hydroxycholesterol, 7β-hydroxycholesterol, and 27-hydroxycholesterol were significantly (P
ISSN:2090-1283
2090-1291
DOI:10.1155/2014/843468