Loading…

Diphtheria outbreak with high mortality in northeastern Nigeria

A diphtheria outbreak occurred from February to November 2011 in the village of Kimba and its surrounding settlements, in Borno State, northeastern Nigeria. We conducted a retrospective outbreak investigation in Kimba village and the surrounding settlements to better describe the extent and clinical...

Full description

Saved in:
Bibliographic Details
Published in:Epidemiology and infection 2014-04, Vol.142 (4), p.797-802
Main Authors: BESA, N.C., COLDIRON, M.E., BAKRI, A., RAJI, A., NSUAMI, M.J., ROUSSEAU, C., HURTADO, N., PORTEN, K.
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c482t-4f618bfc412d4bf5e2b683cb3691429446b10aad40ab4f56c7f8dc5bf84a85833
cites cdi_FETCH-LOGICAL-c482t-4f618bfc412d4bf5e2b683cb3691429446b10aad40ab4f56c7f8dc5bf84a85833
container_end_page 802
container_issue 4
container_start_page 797
container_title Epidemiology and infection
container_volume 142
creator BESA, N.C.
COLDIRON, M.E.
BAKRI, A.
RAJI, A.
NSUAMI, M.J.
ROUSSEAU, C.
HURTADO, N.
PORTEN, K.
description A diphtheria outbreak occurred from February to November 2011 in the village of Kimba and its surrounding settlements, in Borno State, northeastern Nigeria. We conducted a retrospective outbreak investigation in Kimba village and the surrounding settlements to better describe the extent and clinical characteristics of this outbreak. Ninety-eight cases met the criteria of the case definition of diphtheria, 63 (64·3%) of whom were children aged
doi_str_mv 10.1017/S0950268813001696
format article
fullrecord <record><control><sourceid>jstor_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3942815</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>24476853</jstor_id><sourcerecordid>24476853</sourcerecordid><originalsourceid>FETCH-LOGICAL-c482t-4f618bfc412d4bf5e2b683cb3691429446b10aad40ab4f56c7f8dc5bf84a85833</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS1ERactP4AFKFI33YT6ce3YG1BVHq1UtYvC2rIzzsRDJh5sB9R_j6MpLdAFK8s63zm-1wehVwS_JZg0p7dYcUyFlIRhTIQSz9CCgFA1AFbP0WKW61nfRwcprTHGisrmBdqnTAqhCFug9x_8ts-9i95UYco2OvOt-ulzX_V-1VebELMZfL6r_FiN5dI7k7KLY3XtV7PpCO11Zkju5f15iL5--vjl_KK-uvl8eX52Vbcgaa6hE0TargVCl2A77qgVkrWWlSmAKgBhCTZmCdhY6Lhom04uW247CUZyydgherfL3U5245atG3M0g95GvzHxTgfj9d_K6Hu9Cj80U0Al4SXg5D4ghu-TS1lvfGrdMJjRhSlpwgFTSnF57P8opko1nJGCHv-DrsMUx_ITM8UolZLTQpEd1caQUnTdw9wE67lJ_aTJ4nnz58IPjt_VFeD1DlinHOKjDtAIyRn7BYdiokU</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1503228852</pqid></control><display><type>article</type><title>Diphtheria outbreak with high mortality in northeastern Nigeria</title><source>PubMed (Medline)</source><source>Cambridge Journals Online</source><source>JSTOR Archival Journals and Primary Sources Collection</source><creator>BESA, N.C. ; COLDIRON, M.E. ; BAKRI, A. ; RAJI, A. ; NSUAMI, M.J. ; ROUSSEAU, C. ; HURTADO, N. ; PORTEN, K.</creator><creatorcontrib>BESA, N.C. ; COLDIRON, M.E. ; BAKRI, A. ; RAJI, A. ; NSUAMI, M.J. ; ROUSSEAU, C. ; HURTADO, N. ; PORTEN, K.</creatorcontrib><description>A diphtheria outbreak occurred from February to November 2011 in the village of Kimba and its surrounding settlements, in Borno State, northeastern Nigeria. We conducted a retrospective outbreak investigation in Kimba village and the surrounding settlements to better describe the extent and clinical characteristics of this outbreak. Ninety-eight cases met the criteria of the case definition of diphtheria, 63 (64·3%) of whom were children aged &lt;10 years; 98% of cases had never been immunized against diphtheria. None of the 98 cases received diphtheria antitoxin, penicillin, or erythromycin during their illness. The overall case-fatality ratio was 21·4%, and was highest in children aged 10–4 years (42·9%). Low rates of immunization, delayed clinical recognition of diphtheria and absence of treatment with antitoxin and appropriate antibiotics contributed to this epidemic and its severity.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S0950268813001696</identifier><identifier>PMID: 23866913</identifier><language>eng</language><publisher>England: Cambridge University Press</publisher><subject>Adolescent ; Antibiotics ; Antitoxins ; Child ; Child, Preschool ; Diphtheria ; Diphtheria - epidemiology ; Diphtheria - mortality ; Diphtheria toxoid ; Diptheria pertussis tetanus vaccines ; Disease outbreaks ; Disease Outbreaks - statistics &amp; numerical data ; Epidemics ; Epidemiology ; Fatalities ; Female ; Households ; Humans ; Infant ; Infectious diseases ; Male ; Mortality rates ; Nigeria - epidemiology ; Original Papers ; Paediatric Infections ; Penicillin ; Population ; Questionnaires ; Retrospective Studies ; Surveys and Questionnaires ; Tonsillitis ; Vaccines</subject><ispartof>Epidemiology and infection, 2014-04, Vol.142 (4), p.797-802</ispartof><rights>Cambridge University Press 2014</rights><rights>Copyright © Cambridge University Press 2013 The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution license .</rights><rights>Cambridge University Press 2013 2013 Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-4f618bfc412d4bf5e2b683cb3691429446b10aad40ab4f56c7f8dc5bf84a85833</citedby><cites>FETCH-LOGICAL-c482t-4f618bfc412d4bf5e2b683cb3691429446b10aad40ab4f56c7f8dc5bf84a85833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24476853$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24476853$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23866913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BESA, N.C.</creatorcontrib><creatorcontrib>COLDIRON, M.E.</creatorcontrib><creatorcontrib>BAKRI, A.</creatorcontrib><creatorcontrib>RAJI, A.</creatorcontrib><creatorcontrib>NSUAMI, M.J.</creatorcontrib><creatorcontrib>ROUSSEAU, C.</creatorcontrib><creatorcontrib>HURTADO, N.</creatorcontrib><creatorcontrib>PORTEN, K.</creatorcontrib><title>Diphtheria outbreak with high mortality in northeastern Nigeria</title><title>Epidemiology and infection</title><addtitle>Epidemiol Infect</addtitle><description>A diphtheria outbreak occurred from February to November 2011 in the village of Kimba and its surrounding settlements, in Borno State, northeastern Nigeria. We conducted a retrospective outbreak investigation in Kimba village and the surrounding settlements to better describe the extent and clinical characteristics of this outbreak. Ninety-eight cases met the criteria of the case definition of diphtheria, 63 (64·3%) of whom were children aged &lt;10 years; 98% of cases had never been immunized against diphtheria. None of the 98 cases received diphtheria antitoxin, penicillin, or erythromycin during their illness. The overall case-fatality ratio was 21·4%, and was highest in children aged 10–4 years (42·9%). Low rates of immunization, delayed clinical recognition of diphtheria and absence of treatment with antitoxin and appropriate antibiotics contributed to this epidemic and its severity.</description><subject>Adolescent</subject><subject>Antibiotics</subject><subject>Antitoxins</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Diphtheria</subject><subject>Diphtheria - epidemiology</subject><subject>Diphtheria - mortality</subject><subject>Diphtheria toxoid</subject><subject>Diptheria pertussis tetanus vaccines</subject><subject>Disease outbreaks</subject><subject>Disease Outbreaks - statistics &amp; numerical data</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Fatalities</subject><subject>Female</subject><subject>Households</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Male</subject><subject>Mortality rates</subject><subject>Nigeria - epidemiology</subject><subject>Original Papers</subject><subject>Paediatric Infections</subject><subject>Penicillin</subject><subject>Population</subject><subject>Questionnaires</subject><subject>Retrospective Studies</subject><subject>Surveys and Questionnaires</subject><subject>Tonsillitis</subject><subject>Vaccines</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqFkUtv1DAUhS1ERactP4AFKFI33YT6ce3YG1BVHq1UtYvC2rIzzsRDJh5sB9R_j6MpLdAFK8s63zm-1wehVwS_JZg0p7dYcUyFlIRhTIQSz9CCgFA1AFbP0WKW61nfRwcprTHGisrmBdqnTAqhCFug9x_8ts-9i95UYco2OvOt-ulzX_V-1VebELMZfL6r_FiN5dI7k7KLY3XtV7PpCO11Zkju5f15iL5--vjl_KK-uvl8eX52Vbcgaa6hE0TargVCl2A77qgVkrWWlSmAKgBhCTZmCdhY6Lhom04uW247CUZyydgherfL3U5245atG3M0g95GvzHxTgfj9d_K6Hu9Cj80U0Al4SXg5D4ghu-TS1lvfGrdMJjRhSlpwgFTSnF57P8opko1nJGCHv-DrsMUx_ITM8UolZLTQpEd1caQUnTdw9wE67lJ_aTJ4nnz58IPjt_VFeD1DlinHOKjDtAIyRn7BYdiokU</recordid><startdate>20140401</startdate><enddate>20140401</enddate><creator>BESA, N.C.</creator><creator>COLDIRON, M.E.</creator><creator>BAKRI, A.</creator><creator>RAJI, A.</creator><creator>NSUAMI, M.J.</creator><creator>ROUSSEAU, C.</creator><creator>HURTADO, N.</creator><creator>PORTEN, K.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T2</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>20140401</creationdate><title>Diphtheria outbreak with high mortality in northeastern Nigeria</title><author>BESA, N.C. ; COLDIRON, M.E. ; BAKRI, A. ; RAJI, A. ; NSUAMI, M.J. ; ROUSSEAU, C. ; HURTADO, N. ; PORTEN, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c482t-4f618bfc412d4bf5e2b683cb3691429446b10aad40ab4f56c7f8dc5bf84a85833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adolescent</topic><topic>Antibiotics</topic><topic>Antitoxins</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Diphtheria</topic><topic>Diphtheria - epidemiology</topic><topic>Diphtheria - mortality</topic><topic>Diphtheria toxoid</topic><topic>Diptheria pertussis tetanus vaccines</topic><topic>Disease outbreaks</topic><topic>Disease Outbreaks - statistics &amp; numerical data</topic><topic>Epidemics</topic><topic>Epidemiology</topic><topic>Fatalities</topic><topic>Female</topic><topic>Households</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Male</topic><topic>Mortality rates</topic><topic>Nigeria - epidemiology</topic><topic>Original Papers</topic><topic>Paediatric Infections</topic><topic>Penicillin</topic><topic>Population</topic><topic>Questionnaires</topic><topic>Retrospective Studies</topic><topic>Surveys and Questionnaires</topic><topic>Tonsillitis</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BESA, N.C.</creatorcontrib><creatorcontrib>COLDIRON, M.E.</creatorcontrib><creatorcontrib>BAKRI, A.</creatorcontrib><creatorcontrib>RAJI, A.</creatorcontrib><creatorcontrib>NSUAMI, M.J.</creatorcontrib><creatorcontrib>ROUSSEAU, C.</creatorcontrib><creatorcontrib>HURTADO, N.</creatorcontrib><creatorcontrib>PORTEN, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Epidemiology and infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BESA, N.C.</au><au>COLDIRON, M.E.</au><au>BAKRI, A.</au><au>RAJI, A.</au><au>NSUAMI, M.J.</au><au>ROUSSEAU, C.</au><au>HURTADO, N.</au><au>PORTEN, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diphtheria outbreak with high mortality in northeastern Nigeria</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol Infect</addtitle><date>2014-04-01</date><risdate>2014</risdate><volume>142</volume><issue>4</issue><spage>797</spage><epage>802</epage><pages>797-802</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>A diphtheria outbreak occurred from February to November 2011 in the village of Kimba and its surrounding settlements, in Borno State, northeastern Nigeria. We conducted a retrospective outbreak investigation in Kimba village and the surrounding settlements to better describe the extent and clinical characteristics of this outbreak. Ninety-eight cases met the criteria of the case definition of diphtheria, 63 (64·3%) of whom were children aged &lt;10 years; 98% of cases had never been immunized against diphtheria. None of the 98 cases received diphtheria antitoxin, penicillin, or erythromycin during their illness. The overall case-fatality ratio was 21·4%, and was highest in children aged 10–4 years (42·9%). Low rates of immunization, delayed clinical recognition of diphtheria and absence of treatment with antitoxin and appropriate antibiotics contributed to this epidemic and its severity.</abstract><cop>England</cop><pub>Cambridge University Press</pub><pmid>23866913</pmid><doi>10.1017/S0950268813001696</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0950-2688
ispartof Epidemiology and infection, 2014-04, Vol.142 (4), p.797-802
issn 0950-2688
1469-4409
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3942815
source PubMed (Medline); Cambridge Journals Online; JSTOR Archival Journals and Primary Sources Collection
subjects Adolescent
Antibiotics
Antitoxins
Child
Child, Preschool
Diphtheria
Diphtheria - epidemiology
Diphtheria - mortality
Diphtheria toxoid
Diptheria pertussis tetanus vaccines
Disease outbreaks
Disease Outbreaks - statistics & numerical data
Epidemics
Epidemiology
Fatalities
Female
Households
Humans
Infant
Infectious diseases
Male
Mortality rates
Nigeria - epidemiology
Original Papers
Paediatric Infections
Penicillin
Population
Questionnaires
Retrospective Studies
Surveys and Questionnaires
Tonsillitis
Vaccines
title Diphtheria outbreak with high mortality in northeastern Nigeria
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T17%3A23%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Diphtheria%20outbreak%20with%20high%20mortality%20in%20northeastern%20Nigeria&rft.jtitle=Epidemiology%20and%20infection&rft.au=BESA,%20N.C.&rft.date=2014-04-01&rft.volume=142&rft.issue=4&rft.spage=797&rft.epage=802&rft.pages=797-802&rft.issn=0950-2688&rft.eissn=1469-4409&rft_id=info:doi/10.1017/S0950268813001696&rft_dat=%3Cjstor_pubme%3E24476853%3C/jstor_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c482t-4f618bfc412d4bf5e2b683cb3691429446b10aad40ab4f56c7f8dc5bf84a85833%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1503228852&rft_id=info:pmid/23866913&rft_jstor_id=24476853&rfr_iscdi=true