Combined Hepatocellular-Cholangiocarcinoma in a Yellow-Headed Amazon (Amazona oratrix)

A 9-year-old male Yellow-headed Amazon (Amazona oratrix) with a history of anorexia and vomiting died of a liver tumor. The tumor consisted of neoplastic cells with hepatocellular and cholangiocellular differentiations and their intermingled areas. Neoplastic hepatocytes showed islands or trabecular...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2013, Vol.75(11), pp.1507-1510
Main Authors: TENNAKOON, Anusha Hemamali, IZAWA, Takeshi, FUJITA, Daisuke, DENDA, Yuki, SETO, Eiko, SASAI, Hiroshi, KUWAMURA, Mitsuru, YAMATE, Jyoji
Format: Article
Language:English
Subjects:
Amazona
Animals
Bird Diseases - pathology
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - veterinary
Cholangiocarcinoma - pathology
Cholangiocarcinoma - veterinary
combined hepatocellular-cholangiocarcinoma
Fatal Outcome
Histocytochemistry - veterinary
immunohistochemistry
liver
Liver Neoplasms - pathology
Liver Neoplasms - veterinary
Male
Pathology
Yellow-headed Amazon
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Summary:A 9-year-old male Yellow-headed Amazon (Amazona oratrix) with a history of anorexia and vomiting died of a liver tumor. The tumor consisted of neoplastic cells with hepatocellular and cholangiocellular differentiations and their intermingled areas. Neoplastic hepatocytes showed islands or trabecular growth with vacuolated eosinophilic cytoplasm. Cells showing biliary differentiation formed ducts or tubules lined by cytokeratin AE1/AE3-positive epithelia, accompanied by desmoplasia consisting of myofibroblasts reacting to α-smooth muscle actin and desmin. The tumor was diagnosed as a combined hepatocellular-cholangiocarcinoma, which is very rare in the avian.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.13-0192