Detection of enteric pathogens by the nodosome

Highlights • NOD1 and NOD2 monitor the integrity of the cytosol to detect danger signals. • Excessive activation of small Rho GTPases is a danger signal detected by NOD1. • NOD1 detects virulence factors of enteric pathogens that activate small Rho GTPases. • Excessive activation of small Rho GTPase...

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Bibliographic Details
Published in:Trends in immunology 2014-03, Vol.35 (3), p.123-130
Main Authors: Keestra, A. Marijke, Bäumler, Andreas J
Format: Article
Language:English
Subjects:
Acids
Allergy and Immunology
Animals
Autophagy
Bacteria
Bacteria - pathogenicity
Bacterial Infections - immunology
Homeostasis
Humans
Immune system
Immunity, Mucosal - immunology
Insects
Intestines - immunology
Intestines - microbiology
Kinases
Mammals
Nod-like receptors
Nod1 Signaling Adaptor Protein - immunology
Nod2 Signaling Adaptor Protein - immunology
pathogen detection
patterns of pathogenesis
Peptides
Proteins
Recruitment
Signal Transduction - immunology
Small intestine
Surveillance
type III secretions system
Virulence
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Summary:Highlights • NOD1 and NOD2 monitor the integrity of the cytosol to detect danger signals. • Excessive activation of small Rho GTPases is a danger signal detected by NOD1. • NOD1 detects virulence factors of enteric pathogens that activate small Rho GTPases. • Excessive activation of small Rho GTPases is a danger signal in insects and mammals.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2013.10.009