Haemoglobinuria is associated with chronic kidney disease and its progression in patients with sickle cell anaemia

Summary To evaluate the association between haemoglobinuria and chronic kidney disease (CKD) in sickle cell anaemia (SCA), we analysed 356 adult haemoglobin SS or Sβo thalassaemia patients from the University of Illinois at Chicago (UIC) and 439 from the multi‐centre Walk‐Treatment of Pulmonary Hype...

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Bibliographic Details
Published in:British journal of haematology 2014-03, Vol.164 (5), p.729-739
Main Authors: Saraf, Santosh L., Zhang, Xu, Kanias, Tamir, Lash, James P., Molokie, Robert E., Oza, Bharvi, Lai, Catherine, Rowe, Julie H., Gowhari, Michel, Hassan, Johara, DeSimone, Joseph, Machado, Roberto F., Gladwin, Mark T., Little, Jane A., Gordeuk, Victor R.
Format: Article
Language:English
Subjects:
Adult
albuminuria
Albuminuria - etiology
Anemia, Sickle Cell - complications
Anemias. Hemoglobinopathies
Biological and medical sciences
Disease Progression
Diseases of red blood cells
Female
Follow-Up Studies
Glomerular Filtration Rate
haemoglobinuria
haemolysis
Hematologic and hematopoietic diseases
Hemoglobins - metabolism
Hemoglobinuria - diagnosis
Hemoglobinuria - etiology
Humans
kidney disease
Male
Medical sciences
Middle Aged
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - physiopathology
Severity of Illness Index
sickle cell
Tumors
Young Adult
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Summary:Summary To evaluate the association between haemoglobinuria and chronic kidney disease (CKD) in sickle cell anaemia (SCA), we analysed 356 adult haemoglobin SS or Sβo thalassaemia patients from the University of Illinois at Chicago (UIC) and 439 from the multi‐centre Walk‐Treatment of Pulmonary Hypertension and Sickle Cell Disease with Sildenafil Therapy (Walk‐PHaSST) cohort. CKD was classified according to National Kidney Foundation Kidney Disease Outcomes Quality Initiatives guidelines. Haemoglobinuria, defined as positive haem on urine dipstick with absent red blood cells on microscopy, was confirmed by enzyme‐linked immunosorbent assay in a subset of patients. The prevalence of CKD was 58% in the UIC cohort and 54% in the Walk‐PHaSST cohort, and haemoglobinuria was observed in 36% and 20% of the patients, respectively. Pathway analysis in both cohorts indicated an independent association of lactate dehydrogenase with haemoglobinuria and, in turn, independent associations of haemoglobinuria and age with CKD (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.12690