Candidate gene association study for diabetic retinopathy in Chinese patients with type 2 diabetes

To investigate whether variants in a set of eight candidate genes are associated with diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). Case-control study. Patients with T2DM were recruited from the Desheng community in urban Beijing and assigned into a...

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Bibliographic Details
Published in:Molecular vision 2014-03, Vol.20, p.200-214
Main Authors: Yang, Xiufen, Deng, Yu, Gu, Hong, Ren, Xuetao, Li, Na, Lim, Apiradee, Snellingen, Torkel, Liu, Xipu, Wang, Ningli, Liu, Ningpu
Format: Article
Language:English
Subjects:
Alleles
Asian Continental Ancestry Group - genetics
Biomarkers - metabolism
China
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - genetics
Diabetic Retinopathy - complications
Diabetic Retinopathy - genetics
Gene Frequency - genetics
Genetic Association Studies
Genetic Predisposition to Disease
Haplotypes - genetics
Humans
Linkage Disequilibrium - genetics
Multivariate Analysis
Polymorphism, Single Nucleotide - genetics
Risk Factors
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Summary:To investigate whether variants in a set of eight candidate genes are associated with diabetic retinopathy (DR) in a cohort of Chinese patients with type 2 diabetes mellitus (T2DM). Case-control study. Patients with T2DM were recruited from the Desheng community in urban Beijing and assigned into a DR group or diabetic without retinopathy (DWR) group, based on the duration of diabetes and grading of fundus images. Twenty-six single-nucleotide polymorphisms (SNPs) within eight candidate genes, including PPARγ, vascular endothelial growth factor (VEGF) and its receptor kinase insert domain receptor (KDR), erythropoietin, aldose reductase, protein kinase C-β, angiotensin-converting enzyme, and intercellular adhesion molecule 1, were analyzed using the MassARRAY genotyping system. A total of 500 patients with T2DM (216 with DR and 284 with DWR) were enrolled in the study. Significant associations of DR were noted with genotypes of four SNPs-rs699947 (p
ISSN:1090-0535
1090-0535