A recombinant anchorless respiratory syncytial virus (RSV) fusion (F) protein/monophosphoryl lipid A (MPL) vaccine protects against RSV-induced replication and lung pathology

Highlights • Developed a recombinant RSV F-protein based subunit vaccine formulated with monophosphoryl lipid A (MPL). • Vaccine reduced lung viral replication when given in a prime-boost regimen. • Animals vaccinated showed no evidence of exacerbation of lung pathology or induction of cytokine stor...

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Bibliographic Details
Published in:Vaccine 2014-03, Vol.32 (13), p.1495-1500
Main Authors: Blanco, Jorge C.G, Boukhvalova, Marina S, Pletneva, Lioubov M, Shirey, Kari Ann, Vogel, Stefanie N
Format: Article
Language:English
Subjects:
adjuvants
Adjuvants, Immunologic - pharmacology
Administration, Intranasal
agonists
Allergy and Immunology
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Applied microbiology
Baculoviridae
Baculovirus
Biological and medical sciences
Cotton rat
cytokines
F-protein
FI-RSV
Fundamental and applied biological sciences. Psychology
Glycoproteins
Human viral diseases
Immune response
Immunization
immunomodulators
Infectious diseases
innate immunity
lipid A
Lipid A - analogs & derivatives
Lipid A - immunology
Lung - pathology
Lung - virology
lungs
macrophages
Medical sciences
Microbiology
MPL
Pathology
Rats
Recombinant Proteins - immunology
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - prevention & control
Respiratory Syncytial Virus Vaccines - immunology
Respiratory Syncytial Viruses - physiology
Respiratory tract
Rodents
RSV
secondary immunization
Sigmodon
Toll-like receptor 4
Toll-Like Receptor 4 - agonists
vaccination
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Viral Fusion Proteins - immunology
viral load
Virus Replication
viruses
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Description
Summary:Highlights • Developed a recombinant RSV F-protein based subunit vaccine formulated with monophosphoryl lipid A (MPL). • Vaccine reduced lung viral replication when given in a prime-boost regimen. • Animals vaccinated showed no evidence of exacerbation of lung pathology or induction of cytokine storm upon RSV challenge. • MPL acts as an adjuvant and immunomodulatory in the F-protein based vaccine.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.11.032