Unbalanced estrogen metabolism in ovarian cancer

Greater exposure to estrogens is a risk factor for ovarian cancer. To investigate the role of estrogens in ovarian cancer, a spot urine sample and a saliva sample were obtained from 33 women with ovarian cancer and 34 age‐matched controls. Thirty‐eight estrogen metabolites, conjugates and DNA adduct...

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Bibliographic Details
Published in:International journal of cancer 2014-05, Vol.134 (10), p.2414-2423
Main Authors: Zahid, Muhammad, Beseler, Cheryl L., Hall, James B., LeVan, Tricia, Cavalieri, Ercole L., Rogan, Eleanor G.
Format: Article
Language:English
Subjects:
Aged
Aryl Hydrocarbon Hydroxylases - genetics
Aryl Hydrocarbon Hydroxylases - metabolism
Biological and medical sciences
Cancer
Catechol O-Methyltransferase - genetics
Catechol O-Methyltransferase - metabolism
catechol‐O‐methyltransferase
Chromatography, High Pressure Liquid
CYP1B1
Cytochrome P-450 CYP1B1
Deoxyribonucleic acid
DNA
DNA Adducts - chemistry
DNA Adducts - metabolism
DNA Adducts - urine
DNA, Neoplasm - chemistry
DNA, Neoplasm - metabolism
DNA, Neoplasm - urine
Estrogens
Estrogens - chemistry
Estrogens - metabolism
Estrogens - urine
Female
Female genital diseases
Gene Frequency
Genotype
Gynecology. Andrology. Obstetrics
Humans
Linear Models
Medical research
Medical sciences
Metabolites
Middle Aged
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Ovarian cancer
ovarian cancer, estrogen–DNA adducts, unbalanced estrogen metabolism
Ovarian Neoplasms - genetics
Ovarian Neoplasms - metabolism
Ovarian Neoplasms - urine
Polymorphism, Single Nucleotide
Risk Factors
Saliva - chemistry
Saliva - metabolism
SNPs
Tandem Mass Spectrometry
Tumors
Women
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Summary:Greater exposure to estrogens is a risk factor for ovarian cancer. To investigate the role of estrogens in ovarian cancer, a spot urine sample and a saliva sample were obtained from 33 women with ovarian cancer and 34 age‐matched controls. Thirty‐eight estrogen metabolites, conjugates and DNA adducts were analyzed in the urine samples using ultraperformance liquid chromatography/tandem mass spectrometry, and the ratio of adducts to metabolites and conjugates was calculated for each sample. The ratio of depurinating estrogen–DNA adducts to estrogen metabolites and conjugates was significantly higher in cases compared to controls (p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.28565