Rattus norvegicus (Rodentia : Muridae) Infected by Leishmania (Leishmania) infantum (syn. Le. chagasi) in Brazil

In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Se...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Lara-Silva, Fabiana de Oliveira, Barata, Ricardo Andrade, Michalsky, Érika Monteiro, Ferreira, Eduardo de Castro, Lopes, Maria Olímpia Garcia, Pinheiro, Aimara da Costa, Fortes-Dias, Consuelo Latorre, Dias, Edelberto Santos
Format: Article
Language:English
Subjects:
Animals
Brazil
Deoxyribonucleic acid
DNA
DNA - isolation & purification
Dogs
Humans
Leishmania infantum
Leishmania infantum - isolation & purification
Leishmania infantum - pathogenicity
Leishmaniasis - blood
Leishmaniasis - parasitology
Lutzomyia intermedia
Marsupials
Muridae
Parasites
Parasitic diseases
Psychodidae - parasitology
Rats
Rattus norvegicus
Rodentia
Sand & gravel
Small mammals
Urban areas
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Summary:In the present study we surveyed the fauna of phlebotomine sand flies and small mammals in peridomestic areas from a Brazilian municipality where the American cutaneous leishmaniasis (ACL) is endemic. A total of 608 female phlebotomine sand flies were captured during nine months in 2009 and 2010. Seven different species were represented with 60% of them being Lutzomyia intermedia and Lu. whitmani, both incriminated vectors of ACL. Lu. longipalpis, a proven vector of visceral leishmaniasis (VL) was also captured at high proportion (12.8%). Genomic DNA analysis of 136 species-specific pools of female sand flies followed by molecular genotyping showed the presence of Leishmania infantum DNA in two pools of Lu. longipalpis. The same Leishmania species was found in one blood sample from Rattus norvegicus among 119 blood and tissue samples analysed. This is the first report of Le. infantum in R. norvegicus in the Americas and suggests a possible role for this rodent species in the zoonotic cycle of VL. Our study coincided with the reemergence of VL in Governador Valadares.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/592986