Adrenomedullin protects from experimental autoimmune encephalomyelitis at multiple levels

Highlight • Adrenomedullin is a neuropeptide with therapeutic effects in EAE which acts at multiple levels on the autoimmune, inflammatory and degenerative components of the disease.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2014-03, Vol.37, p.152-163
Main Authors: Pedreño, Marta, Morell, Maria, Robledo, Gema, Souza-Moreira, Luciana, Forte-Lago, Irene, Caro, Marta, O’Valle, Francisco, Ganea, Doina, Gonzalez-Rey, Elena
Format: Article
Language:English
Subjects:
Adrenomedullin
Adrenomedullin - therapeutic use
Allergy and Immunology
Animals
Autoimmunity
Brain - drug effects
Brain - immunology
Chronic Disease
Cytokines - metabolism
Dendritic cells
Encephalomyelitis, Autoimmune, Experimental - drug therapy
Encephalomyelitis, Autoimmune, Experimental - immunology
Female
Glial cells
Lymph Nodes - drug effects
Lymph Nodes - immunology
Mice
Mice, Inbred C57BL
Multiple sclerosis
Neuropeptide
Neuroprotective Agents - therapeutic use
Psychiatry
Regulatory T cells
Spinal Cord - drug effects
Spinal Cord - immunology
Spleen - drug effects
Spleen - immunology
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Description
Summary:Highlight • Adrenomedullin is a neuropeptide with therapeutic effects in EAE which acts at multiple levels on the autoimmune, inflammatory and degenerative components of the disease.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2013.11.021