Activation of D2 -like dopamine receptors inhibits GABA and glycinergic neurotransmission to pre-motor cardiac vagal neurons in the nucleus ambiguus

Highlights • Dopamine, via D2 -like receptors, suppresses GABA and glycinergic synaptic activity to CVNs. • Dopamine effects on inhibitory neurotransmission were action potential dependent. • Dis-inhibition of CVNs by dopamine would be predicted to increase vagal activity to the heart.

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Bibliographic Details
Published in:Neuroscience 2013-09, Vol.247, p.213-226
Main Authors: Dyavanapalli, J, Byrne, P, Mendelowitz, D
Format: Article
Language:English
Subjects:
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology
Animals
Biological and medical sciences
dopamine
Excitatory Postsynaptic Potentials - drug effects
Excitatory Postsynaptic Potentials - physiology
Fundamental and applied biological sciences. Psychology
GABAergic Neurons - drug effects
GABAergic Neurons - physiology
Glycine - antagonists & inhibitors
Glycine - physiology
heart rate
Inhibitory Postsynaptic Potentials - drug effects
Inhibitory Postsynaptic Potentials - physiology
Neural Inhibition - drug effects
Neural Inhibition - physiology
Neurology
nucleus ambiguus
parasympathetic
Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ
Rats
Rats, Sprague-Dawley
Receptors, Dopamine D2 - agonists
Receptors, Dopamine D2 - metabolism
Synaptic Transmission - drug effects
Synaptic Transmission - physiology
Vagus Nerve - drug effects
Vagus Nerve - physiology
Vertebrates: nervous system and sense organs
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Description
Summary:Highlights • Dopamine, via D2 -like receptors, suppresses GABA and glycinergic synaptic activity to CVNs. • Dopamine effects on inhibitory neurotransmission were action potential dependent. • Dis-inhibition of CVNs by dopamine would be predicted to increase vagal activity to the heart.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.05.039