Does Loop Electrosurgical Excision Procedure of the Uterine Cervix Affect Anti-Müllerian Hormone Levels?

Background. A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decre...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-6
Main Authors: Sklavos, Martha M., Spracklen, Cassandra N., Saftlas, Audrey F., Pinto, Ligia A.
Format: Article
Language:English
Subjects:
Anti-Mullerian Hormone - biosynthesis
Anti-Mullerian Hormone - metabolism
Anti-Müllerian hormone
Biomedical research
Care and treatment
Cervical cancer
Cervix Uteri - metabolism
Cervix Uteri - pathology
Cervix Uteri - surgery
Complications and side effects
Electrosurgery
Electrosurgery - adverse effects
Excision (Surgery)
Female
Health aspects
Human papillomavirus
Humans
Infertility
Medical research
Menstruation
Pregnancy
Uterine Cervical Dysplasia - metabolism
Uterine Cervical Dysplasia - pathology
Uterine Cervical Dysplasia - surgery
Womens health
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Summary:Background. A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-Müllerian hormone (AMH), a marker of ovarian reserve. Methods. AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP. Cases and controls had their blood drawn at study entry time zero and again 6 months later. Results. The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggesting that both groups experienced a similar decrease in AMH levels during the follow-up period. Although women treated with LEEP had lower overall AMH levels than controls at both baseline and follow-up, these differences were not statistically significant. Conclusion. Overall, the delayed time to pregnancy observed in women treated with LEEP is likely not due to a LEEP-associated decrease in ovarian reserve as measured by AMH; thus, other mechanism are responsible for the delayed time to pregnancy associated with LEEP.
ISSN:2314-6133
2314-6141
2314-6141
DOI:10.1155/2014/875438