Translational Research Using a Mouse Model of Intracranial Aneurysm

We have developed a mouse model of intracranial aneurysm that recapitulates key features of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs with a predictable time course. Aneurysmal rupture in this model can be easily detected by assessing neurological symptoms. S...

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Bibliographic Details
Published in:Translational stroke research 2014-04, Vol.5 (2), p.248-251
Main Authors: Wada, Kosuke, Makino, Hiroshi, Shimada, Kenji, Shikata, Fumiaki, Kuwabara, Atsushi, Hashimoto, Tomoki
Format: Article
Language:English
Subjects:
Aneurysms
Animals
Asymptomatic
Biomedical and Life Sciences
Biomedicine
Brain research
Cardiology
Cerebrospinal fluid
Disease Models, Animal
Hemorrhage
Hypertension
Intracranial Aneurysm - pathology
Mice
Mortality
Neurology
Neurosciences
Neurosurgery
Original Article
Prevention
Rupture, Spontaneous - pathology
Translational Medical Research
Vascular Surgery
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Summary:We have developed a mouse model of intracranial aneurysm that recapitulates key features of human intracranial aneurysms. In this model, spontaneous aneurysmal rupture occurs with a predictable time course. Aneurysmal rupture in this model can be easily detected by assessing neurological symptoms. Similar to human intracranial aneurysms, intracranial aneurysms in this model show an infiltration with inflammatory cells. This mouse model can be used to study the mechanisms and the potential preventive treatments for aneurysmal rupture.
ISSN:1868-4483
1868-601X
DOI:10.1007/s12975-013-0296-8