RANKL Expression in Periodontal Disease : Where Does RANKL Come from?

Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Chen, Bin, Wu, Wenlei, Sun, Weibin, Zhang, Qian, Yan, Fuhua, Xiao, Yin
Format: Article
Language:English
Subjects:
Alveolar Bone Loss - metabolism
Alveolar Bone Loss - pathology
Animals
Cell receptors
Development and progression
Disease
Gene Expression Regulation
Health aspects
Humans
Immune system
Lymphocytes
Microorganisms
Oral hygiene
Osteoclasts - metabolism
Osteoclasts - pathology
Periodontal disease
RANK Ligand - biosynthesis
Review
Studies
Tumor necrosis factor
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Summary:Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-κB ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/731039