TSPAN33 is a novel marker of activated and malignant B cells

Abstract We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B...

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Published in:Clinical immunology (Orlando, Fla.) Fla.), 2013-12, Vol.149 (3), p.388-399
Main Authors: Luu, Van Phi, Hevezi, Peter, Vences-Catalan, Felipe, Maravillas-Montero, José Luis, White, Clayton Alexander, Casali, Paolo, Llorente, Luis, Jakez-Ocampo, Juan, Lima, Guadalupe, Vilches-Cisneros, Natalia, Flores-Gutiérrez, Juan Pablo, Santos-Argumedo, Leopoldo, Zlotnik, Albert
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
B cells
B-Lymphocytes - drug effects
B-Lymphocytes - immunology
B-Lymphocytes - pathology
Biomarker
Biomarkers - metabolism
Case-Control Studies
Cell Line
Female
Gene Expression Profiling
Gene Expression Regulation
Humans
Lipopolysaccharides - pharmacology
Lupus erythematosus
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - immunology
Lupus Erythematosus, Systemic - pathology
Lymphocyte Activation
Lymphoma
Male
Mice
Mice, Transgenic
Organ Specificity
Primary Cell Culture
Rheumatoid arthritis
Signal Transduction
Tetradecanoylphorbol Acetate - pharmacology
Tetraspanin 33
Tetraspanins - genetics
Tetraspanins - immunology
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Summary:Abstract We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Faslpr/lpr mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
ISSN:1521-6616
1521-7035
DOI:10.1016/j.clim.2013.08.005