The Preoperative Maximum Standardized Uptake Value Measured by 18F-FDG PET/CT as an Independent Prognostic Factor of Overall Survival in Endometrial Cancer Patients

Purpose. The aim of this study was to determine if the preoperative maximum standardized uptake value (SUVmax) measured by 18F-FDG PET/CT in the primary tumor has prognostic value in the group of patients with endometrial cancer. Patients, Materials, and Methods. A total of one hundred one consecuti...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-7
Main Authors: Małkowski, Bogdan, Sadlecki, Pawel, Walentowicz-Sadlecka, Małgorzata, Grabiec, Marek, Pietrzak, Tomasz, Marszalek, Andrzej, Walentowicz, Pawel
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological specimens
Chemotherapy
Clinical Study
Disease-Free Survival
Endometrial cancer
Endometrial Neoplasms - diagnosis
Endometrial Neoplasms - pathology
Endometrial Neoplasms - surgery
Female
Fertility
Fluorodeoxyglucose F18
Glucose
Gynecology
Humans
Lymphatic system
Medical prognosis
Metastasis
Middle Aged
Multivariate analysis
Neoplasm Recurrence, Local - diagnosis
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Neoplasm Staging
Nuclear medicine
Obstetrics
Oncology
PET imaging
Positron-Emission Tomography
Preoperative Care
Prognosis
Risk factors
Surgery
Tomography, X-Ray Computed
Womens health
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Summary:Purpose. The aim of this study was to determine if the preoperative maximum standardized uptake value (SUVmax) measured by 18F-FDG PET/CT in the primary tumor has prognostic value in the group of patients with endometrial cancer. Patients, Materials, and Methods. A total of one hundred one consecutive endometrial cancer patients, age range 40–82 years (mean 62 years) and FIGO I–IV stage, who underwent 18-FDG-PET/CT within two weeks prior radical surgery, were enrolled to the study. The maximum SUV was measured and compared with the clinicopathologic features of surgical specimens. The relationship between SUVmax and overall survival was analyzed. Results. The mean preoperative SUVmax was 14.34; range (3.90–33.80) and was significantly lower for FIGO I than for higher stages (P=0.0012), as well as for grade 1 than for grade 2 and 3 (P=0.018), deep myometrial invasion (P=0.0016) and for high risk group (P=0.0004). The analysis of survival ROC curve revealed SUVmax cut-off value of 17.7 to predict high risk of recurrence. Endometrial cancer patients with SUVmax higher than 17.7 characterized by lower overall survival. Conclusion. The preoperative SUVmax measured by 18F-FDG PET/CT is considered as an important indicator reflecting tumor aggressiveness which may predict poor prognosis. High value of SUVmax would be useful for making noninvasive diagnoses and deciding the appropriate therapeutic strategy for patients with endometrial cancer.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/234813