Visualizing epigenetics: Current advances and advantages in HDAC PET imaging techniques

Highlights • Invasive measurements of epigenetics can be conceptually adapted for human brain imaging. • Noninvasive measurements of HDAC expression and function are being developed. • Functional consequences of epigenetic modulation can be imaged with PET and fMRI.

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Bibliographic Details
Published in:Neuroscience 2014-04, Vol.264, p.186-197
Main Authors: Wang, C, Schroeder, F.A, Hooker, J.M
Format: Article
Language:English
Subjects:
Brain - diagnostic imaging
Brain - enzymology
Epigenomics - methods
Histone Deacetylases - analysis
Histone Deacetylases - metabolism
Humans
Neurology
Positron-Emission Tomography - methods
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Description
Summary:Highlights • Invasive measurements of epigenetics can be conceptually adapted for human brain imaging. • Noninvasive measurements of HDAC expression and function are being developed. • Functional consequences of epigenetic modulation can be imaged with PET and fMRI.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2013.09.018