CEACAM1 in Cervical Cancer and Precursor Lesions: Association With Human Papillomavirus Infection

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an adhesion molecule expressed in a wide variety of tissues including epithelial cells, leukocytes, and tumors that may establish both homotypic and heterotypic interactions. The aim of this work was to study the protein expressi...

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Bibliographic Details
Published in:The journal of histochemistry and cytochemistry 2006-12, Vol.54 (12), p.1393-1399
Main Authors: Albarran-Somoza, Benibelks, Franco-Topete, Ramon, Delgado-Rizo, Vidal, Cerda-Camacho, Felipe, Acosta-Jimenez, Lourdes, Lopez-Botet, Miguel, Daneri-Navarro, Adrian
Format: Article
Language:English
Subjects:
Adult
Antigens, CD - analysis
Antigens, CD - biosynthesis
Cell Adhesion Molecules - analysis
Cell Adhesion Molecules - biosynthesis
Cervical Intraepithelial Neoplasia - chemistry
Cervical Intraepithelial Neoplasia - pathology
Cervical Intraepithelial Neoplasia - virology
Disease Progression
Female
Humans
Immunohistochemistry
Middle Aged
Papillomavirus Infections - complications
Papillomavirus Infections - pathology
Polymerase Chain Reaction
Precancerous Conditions - chemistry
Precancerous Conditions - pathology
Precancerous Conditions - virology
Sensitivity and Specificity
Uterine Cervical Neoplasms - chemistry
Uterine Cervical Neoplasms - pathology
Uterine Cervical Neoplasms - virology
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Summary:Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is an adhesion molecule expressed in a wide variety of tissues including epithelial cells, leukocytes, and tumors that may establish both homotypic and heterotypic interactions. The aim of this work was to study the protein expression pattern of CEACAM1 in cervical cancer and precursor lesions in the context of human papillomavirus (HPV) infection. We used immunohistochemistry to analyze CEACAM1 expression in formalin-fixed, paraffin-embedded cervical tissues from 15 healthy women, 15 patients with low-grade squamous intraepithelial lesions (SIL), 15 patients with high-grade SIL, and 15 patients with squamous carcinomas. HPV types were identified by PCR. CEACAM1 was either undetectable (13/15) or low (2/15) in normal cervical tissues. By contrast, CEACAM1 expression was increased in high-grade SIL (10 samples staining intermediate/high and 4 samples staining low) as compared with low-grade SIL with undetectable (n=3) or low (n= 12) expression. CEACAM1 expression was undetectable or low in cervical carcinoma. Our results suggest that CEACAM1 may be an interesting progression marker in SIL and cervical cancer, in particular due to reported immunoregulatory properties.
ISSN:0022-1554
1551-5044
DOI:10.1369/jhc.6A6921.2006