Human papillomavirus, p16INK4A, and Ki-67 in relation to clinicopathological variables and survival in primary carcinoma of the vagina

Background: This study aimed to determine human papillomavirus (HPV) status and to investigate p16 INK4A and Ki-67 expression and their correlation with clinical parameters and survival in women with primary carcinoma of the vagina (PCV). Methods: The presence of HPV DNA was evaluated by PCR. Genoty...

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Bibliographic Details
Published in:British journal of cancer 2014-03, Vol.110 (6), p.1561-1570
Main Authors: Hellman, K, Lindquist, D, Ranhem, C, Wilander, E, Andersson, S
Format: Article
Language:English
Subjects:
692/53/2422
692/699/67/1517
692/699/67/1858
Biological and medical sciences
Biomarkers
Biomedical and Life Sciences
Biomedicine
Biopsy
Cancer
Cancer Research
Cervix
Drug Resistance
Epidemiology
Gynecology
Human papillomavirus
Infectious diseases
Medical prognosis
Medical research
Medical sciences
Molecular Diagnostics
Molecular Medicine
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Obstetrics
Oncology
Proteins
Tumors
Vagina
Viral diseases
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Summary:Background: This study aimed to determine human papillomavirus (HPV) status and to investigate p16 INK4A and Ki-67 expression and their correlation with clinical parameters and survival in women with primary carcinoma of the vagina (PCV). Methods: The presence of HPV DNA was evaluated by PCR. Genotyping was performed by Luminex in 68 short-term (⩽2 years) and long-term (⩾8 years) PCV survivors. p16 INK4A and Ki-67 expression was evaluated by immunohistochemistry. Results: Human papillomavirus DNA was detected in 43% of patients, the majority (63%) of whom were HPV16 positive. High p16 INK4A expression was significantly correlated with low histopathological grade ( P =0.004), HPV positivity ( P =0.032), and long-term survival ( P =0.045). High Ki-67 expression was negatively correlated with histopathological grade ( P
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.2014.32