Efficacy of Helicobacter pylori eradication for the prevention of metachronous gastric cancer after endoscopic resection for early gastric cancer

Helicobacter pylori(H.pylori)plays an important role in gastric carcinogenesis,as the majority of gastric cancers develop from H.pylori-infected gastric mucosa.The rate of early gastric cancer diagnosis has increased in Japan and Korea,where H.pylori infection and gastric cancer are highly prevalent...

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Bibliographic Details
Published in:World journal of gastroenterology : WJG 2014-03, Vol.20 (11), p.2760-2764
Main Authors: Jang, Jae Young, Chun, Hoon Jai
Format: Article
Language:English
Subjects:
cancer
Endoscopic
Gastric
Gastroscopy
Helicobacter
Helicobacter Infections - complications
Helicobacter Infections - therapy
Humans
Neoplasms, Second Primary - microbiology
Neoplasms, Second Primary - prevention & control
pylori
rese
Stomach Neoplasms - microbiology
Stomach Neoplasms - prevention & control
Stomach Neoplasms - surgery
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Summary:Helicobacter pylori(H.pylori)plays an important role in gastric carcinogenesis,as the majority of gastric cancers develop from H.pylori-infected gastric mucosa.The rate of early gastric cancer diagnosis has increased in Japan and Korea,where H.pylori infection and gastric cancer are highly prevalent.Early intestinal-type gastric cancer without concomitant lymph node metastasis is usually treated by endoscopic resection.Secondary metachronous gastric cancers often develop because atrophic mucosa left untreated after endoscopic treatment confers a high risk of gastric cancer.The efficacy of H.pylori eradication for the prevention of metachronous gastric cancer remains controversial.However,in patients who undergo endoscopic resection of early gastric cancer,H.pylori eradication is recommended to suppress or delay metachronous gastric cancer.Careful and regularly scheduled endoscopy should be performed to detect minute metachronous gastric cancer after endoscopic resection.
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.v20.i11.2760