A Comparison of Cervical and Vaginal Human Papillomavirus

Objectives: We wanted to compare detection of a broad spectrum of human papillomavirus (HPV) types detected in cellular specimens from the vagina and cervix, which could provide information about the potential of each anatomical site for harboring infection. Previous studies have failed to present d...

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Bibliographic Details
Published in:Sexually transmitted diseases 2007-11, Vol.34 (11), p.849-855
Main Authors: CASTLE, PHILIP E., RODRIGUEZ, ANA C., PORRAS, CAROLINA, HERRERO, ROLANDO, SCHIFFMAN, MARK, GONZALEZ, PAULA, HILDESHEIM, ALLAN, BURK, ROBERT D.
Format: Article
Language:English
Subjects:
Adult
Affinity
Aged
Aged, 80 and over
Biological and medical sciences
Cells
Cervical Intraepithelial Neoplasia - epidemiology
Cervical Intraepithelial Neoplasia - virology
Cervix Uteri - virology
Cohort Studies
Contamination
Costa Rica - epidemiology
DNA, Viral - analysis
Epidemiology. Vaccinations
Female
General aspects
Genotype & phenotype
Human infectious diseases. Experimental studies and models
Human papillomavirus
Human papillomaviruses
Humans
Infectious diseases
Medical sciences
Middle Aged
Papillomaviridae - classification
Papillomaviridae - genetics
Papillomaviridae - isolation & purification
Papillomavirus Infections - epidemiology
Papillomavirus Infections - virology
Phylogeny
Polymerase Chain Reaction
Prevalence
Reproductive system
Sexually transmitted diseases
STD
Uterine Cervical Neoplasms - epidemiology
Uterine Cervical Neoplasms - virology
Vagina
Vagina - virology
Vaginal Smears
Women
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Summary:Objectives: We wanted to compare detection of a broad spectrum of human papillomavirus (HPV) types detected in cellular specimens from the vagina and cervix, which could provide information about the potential of each anatomical site for harboring infection. Previous studies have failed to present data on or detect a broad spectrum of HPV genotypes and/or have not carefully sampled the vagina, instead relying on self-collection that is likely contaminated with cervical cells. Study Design: We conducted follow-up study of 353 women who had participated in study of HPV and cervical neoplasia in Costa Rica. We collected paired cervical and vaginal specimens; vaginal specimens were collected from the fornix to minimize cervical contamination. Specimens were tested in a masked fashion for >40 HPV types using a MY09/MY11 PCR method and type-specific dot blot hybridization. Results: The prevalence for any carcinogenic HPV type in vaginal and cervical specimens was similar (P = 0.3). However, the prevalence for any HPV type in vaginal specimens was greater than in cervical specimens (P = 0.0002), primarily due to a twofold increased vaginal prevalence of HPV types of the α3/α15 phylogenetic species (e.g., HPV61) (P
ISSN:0148-5717
1537-4521
DOI:10.1097/OLQ.0b013e318064c8c5