Updates on the web-based VIOLIN vaccine database and analysis system

The integrative Vaccine Investigation and Online Information Network (VIOLIN) vaccine research database and analysis system (http://www.violinet.org) curates, stores, analyses and integrates various vaccine-associated research data. Since its first publication in NAR in 2008, significant updates hav...

Full description

Saved in:
Bibliographic Details
Published in:Nucleic acids research 2014-01, Vol.42 (Database issue), p.D1124-D1132
Main Authors: He, Yongqun, Racz, Rebecca, Sayers, Samantha, Lin, Yu, Todd, Thomas, Hur, Junguk, Li, Xinna, Patel, Mukti, Zhao, Boyang, Chung, Monica, Ostrow, Joseph, Sylora, Andrew, Dungarani, Priya, Ulysse, Guerlain, Kochhar, Kanika, Vidri, Boris, Strait, Kelsey, Jourdian, George W, Xiang, Zuoshuang
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic
Antigens - chemistry
Antigens - genetics
Data Mining
Databases, Genetic
Genes
Genomics
Humans
Internet
Plasmids - genetics
Proteins - immunology
Sequence Alignment
Software
Systems Integration
Vaccines - adverse effects
Vaccines - chemistry
Vaccines - genetics
Vaccines - immunology
Vaccines, Attenuated - genetics
Vaccines, DNA - genetics
VI. Genomic variation, diseases and drugs
Virulence Factors - genetics
Virulence Factors - immunology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The integrative Vaccine Investigation and Online Information Network (VIOLIN) vaccine research database and analysis system (http://www.violinet.org) curates, stores, analyses and integrates various vaccine-associated research data. Since its first publication in NAR in 2008, significant updates have been made. Starting from 211 vaccines annotated at the end of 2007, VIOLIN now includes over 3240 vaccines for 192 infectious diseases and eight noninfectious diseases (e.g. cancers and allergies). Under the umbrella of VIOLIN, >10 relatively independent programs are developed. For example, Protegen stores over 800 protective antigens experimentally proven valid for vaccine development. VirmugenDB annotated over 200 'virmugens', a term coined by us to represent those virulence factor genes that can be mutated to generate successful live attenuated vaccines. Specific patterns were identified from the genes collected in Protegen and VirmugenDB. VIOLIN also includes Vaxign, the first web-based vaccine candidate prediction program based on reverse vaccinology. VIOLIN collects and analyzes different vaccine components including vaccine adjuvants (Vaxjo) and DNA vaccine plasmids (DNAVaxDB). VIOLIN includes licensed human vaccines (Huvax) and veterinary vaccines (Vevax). The Vaccine Ontology is applied to standardize and integrate various data in VIOLIN. VIOLIN also hosts the Ontology of Vaccine Adverse Events (OVAE) that logically represents adverse events associated with licensed human vaccines.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gkt1133