Dynamical changes in neurological diseases and anesthesia

Highlights ► We examine changes in structure versus changes in currents in the microcircuits of two neurological diseases. ► Some aspects of Parkinson's disease may result from aberrant expressions of normal networks. ► Changes in dynamics in schizophrenia may lead to compensatory structural ch...

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Bibliographic Details
Published in:Current opinion in neurobiology 2012-08, Vol.22 (4), p.693-703
Main Authors: McCarthy, Michelle M, Ching, ShiNung, Whittington, Miles A, Kopell, Nancy
Format: Article
Language:English
Subjects:
Anesthesia
Anesthetics - pharmacology
gamma-Aminobutyric Acid - metabolism
Humans
Models, Neurological
Nerve Net - drug effects
Nerve Net - physiopathology
Nervous System Diseases - drug therapy
Nervous System Diseases - pathology
Neurology
Neurons - drug effects
Neurons - physiology
Nonlinear Dynamics
Psychiatry
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Summary:Highlights ► We examine changes in structure versus changes in currents in the microcircuits of two neurological diseases. ► Some aspects of Parkinson's disease may result from aberrant expressions of normal networks. ► Changes in dynamics in schizophrenia may lead to compensatory structural changes. ► Changes in network behavior in anesthesia illustrate changes in dynamics without structural changes.
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2012.02.009