Gold nanoparticle mediated cancer immunotherapy

Abstract Significant progress has been made in the field of cancer immunotherapy, where the goal is to activate or modulate the body's immune response against cancer. However, current immunotherapy approaches exhibit limitations of safety and efficacy due to systemic delivery. In this context,...

Full description

Saved in:
Bibliographic Details
Published in:Nanomedicine 2014-04, Vol.10 (3), p.503-514
Main Authors: Almeida, Joao Paulo Mattos, BS, Figueroa, Elizabeth Raquel, BS, Drezek, Rebekah Anna, PhD
Format: Article
Language:English
Subjects:
Adjuvants, Immunologic - administration & dosage
Adjuvants, Immunologic - therapeutic use
Animals
Biodistribution
Cancer
Cancer Vaccines - administration & dosage
Cancer Vaccines - therapeutic use
Drug Carriers - chemistry
Drug Carriers - pharmacokinetics
Gene Transfer Techniques
Genetic Therapy - methods
Gold - chemistry
Gold - immunology
Gold - pharmacokinetics
Gold nanoparticles
Humans
Immune system
Immunotherapy
Immunotherapy - methods
Internal Medicine
Nanomedicine - methods
Nanoparticles - chemistry
Nanoparticles - metabolism
Neoplasms - genetics
Neoplasms - immunology
Neoplasms - therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Significant progress has been made in the field of cancer immunotherapy, where the goal is to activate or modulate the body's immune response against cancer. However, current immunotherapy approaches exhibit limitations of safety and efficacy due to systemic delivery. In this context, the use of nanotechnology for the delivery of cancer vaccines and immune adjuvants presents a number of advantages such as targeted delivery to immune cells, enhanced therapeutic effect, and reduced adverse outcomes. Recently, gold nanoparticles (AuNP) have been explored as immunotherapy carriers, creating new AuNP applications that merit a critical overview. This review highlights recent advances in the development of AuNP mediated immunotherapies that harness AuNP biodistribution, optical properties and their ability to deliver macromolecules such as peptides and oligonucleotides. It has been demonstrated that the use of AuNP carriers can improve the delivery and safety of immunotherapy agents, and that AuNP immunotherapies are well suited for synergistic combination therapy with existing cancer therapies like photothermal ablation. From the Clinical Editor Cancer immunotherapy approaches are rapidly evolving and are some of the most promising avenues to approach malignancies. This review summarizes the role of gold nanoparticles in immunotherapy agent delivery, and in the development of synergistic therapies such as photothermal ablation.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2013.09.011