Lipid-lowering effects of Pediococcus acidilactici M76 isolated from Korean traditional makgeolli in high fat diet-induced obese mice

The effect of Pediococcus acidilactici M76 (lactic acid bacteria) isolated from makgeolli on mice fed a high fat diet was investigated to clarify the lipid lowering function. C57BL/6J male mice were randomly divided into a normal diet (ND) group, high fat diet (HD) group, HD plus Pediococcus acidila...

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Bibliographic Details
Published in:Nutrients 2014-03, Vol.6 (3), p.1016-1028
Main Authors: Moon, Yeon-Jeong, Baik, Sang-Ho, Cha, Youn-Soo
Format: Article
Language:English
Subjects:
adipose tissue
Adipose Tissue - metabolism
Alanine Transaminase - blood
Alcohol
Alcoholic Beverages - microbiology
animal disease models
Animals
Aspartate Aminotransferases - blood
Body fat
Body Weight
Cholesterol - blood
Diet
Diet, High-Fat
Energy Intake
Enzymes
Food
freeze drying
high fat diet
Hypolipidemic Agents
Insulin - blood
Insulin resistance
lactic acid bacteria
Leptin - blood
lipemic effect
lipid composition
Lipids
Lipogenesis - physiology
Liver - metabolism
Male
males
Metabolism
Mice
Mice, Inbred C57BL
Mice, Obese
Nutrition research
Obesity
Obesity - metabolism
Obesity - therapy
Pediococcus - isolation & purification
Pediococcus acidilactici
peroxisome proliferator-activated receptor gamma
PPAR gamma - genetics
PPAR gamma - metabolism
Rice
RNA, Messenger - genetics
RNA, Messenger - metabolism
tissue weight
Triglycerides - blood
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Summary:The effect of Pediococcus acidilactici M76 (lactic acid bacteria) isolated from makgeolli on mice fed a high fat diet was investigated to clarify the lipid lowering function. C57BL/6J male mice were randomly divided into a normal diet (ND) group, high fat diet (HD) group, HD plus Pediococcus acidilactici DSM 20284 reference strain (PR) group, and HD plus Pediococcus acidilactici M76 strain (PA) groups. The lyophilized PA and PR strain were dissolved in distilled water at a final concentration of 1.25 × 10⁹ cfu/mL and was given orally to animals at a dose of 4 mL/kg body weight for 12 weeks. The PA group had a lower final body weight, adipose tissue weight, and lipid profile than those in the HD group. Additionally, level of ACC, FAS and PPAR-γ, a key lipid synthesis enzyme, was markedly suppressed in the PA compared to those in the HD group. These data suggest that P. acidilactici M76 may exert a lipid-lowering effect in high fat diet-induced obese mice.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu6031016