Roux en Y Gastric Bypass Increases Ethanol Intake in the Rat

Roux en Y gastric bypass (RYGB) surgery is currently the most effective therapy employed to treat obesity and its associated complications. In addition to weight loss and resolution of metabolic syndromes, such as diabetes, the RYGB procedure has been reported to increase alcohol consumption in huma...

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Bibliographic Details
Published in:Obesity surgery 2013-07, Vol.23 (7), p.920-930
Main Authors: Davis, Jon F., Tracy, Andrea L., Schurdak, Jennifer D., Magrisso, Irwin J., Grayson, Bernadette E., Seeley, Randy J., Benoit, Stephen C.
Format: Article
Language:English
Subjects:
Alcohol Drinking
Alcohol use
Animal behavior
Animal Research
Animals
Behavior, Animal
Body Weight
Choice Behavior
Dopamine
Ethanol - administration & dosage
Ethanol - blood
Ethanol - metabolism
Gastric Bypass - adverse effects
Gastrointestinal surgery
Ghrelin - blood
Hippocampus - physiopathology
Male
Medicine
Medicine & Public Health
Neural Pathways - physiopathology
Obesity - surgery
Postoperative Period
Rats
Rats, Long-Evans
Reward
Rodents
Surgery
Weight Loss
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Summary:Roux en Y gastric bypass (RYGB) surgery is currently the most effective therapy employed to treat obesity and its associated complications. In addition to weight loss and resolution of metabolic syndromes, such as diabetes, the RYGB procedure has been reported to increase alcohol consumption in humans. Using an outbred rodent model, we demonstrate that RYGB increases postsurgical ethanol consumption, that this effect cannot be explained solely by postsurgical weight loss and that it is independent of presurgical body weight or dietary composition. Altered ethanol metabolism and postsurgical shifts in release of ghrelin were also unable to account for changes in alcohol intake. Further investigation of the potential physiological factors underlying this behavioral effect identified altered patterns of gene expression in brain regions associated with reward following RYGB surgery. These findings have important clinical implications as they demonstrate that RYGB surgery leads directly to increased alcohol intake in otherwise alcohol nonpreferring rat and induces neurobiological changes in brain circuits that mediate a variety of appetitive behaviors.
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-013-0884-4