Dietary Influence on MAPK-Signaling Pathways and Risk of Colon and Rectal Cancer

• Published in: Nutrition and cancer 2013-07, Vol.65 (5), p.729-738
• Main Authors: Slattery, Martha L, Lundgreen, Abbie, Wolff, Roger K
• Format: Article
• Language: English
• Subjects: administration & dosage; Adult; Aged; apoptosis; ascorbic acid; calcium; Calcium, Dietary; Calcium, Dietary - administration & dosage; Carotenoids; Carotenoids - administration & dosage; Case-Control Studies; cell proliferation; chemistry; colon; Colonic Neoplasms; Colonic Neoplasms - genetics; Colonic Neoplasms - prevention & control; Colorectal cancer; colorectal neoplasms; Diet; Dietary Carbohydrates; Dietary Carbohydrates - administration & dosage; dietary fat; Dietary Fats; Dietary Fats - administration & dosage; drug effects; Energy Intake; Female; folic acid; Folic Acid - administration & dosage; Genes; genetics; growth factors; Humans; inflammation; iron; JNK Mitogen-Activated Protein Kinases; JNK Mitogen-Activated Protein Kinases - genetics; JNK Mitogen-Activated Protein Kinases - metabolism; Logistic Models; lutein; lycopene; Male; MAP Kinase Signaling System; metabolism; Middle Aged; mitogen-activated protein kinase; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 3 - genetics; Mitogen-Activated Protein Kinase 3 - metabolism; mutagenicity; oxidative stress; Oxidative Stress - drug effects; p38 Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases - genetics; prevention & control; Rectal Neoplasms; Rectal Neoplasms - genetics; Rectal Neoplasms - prevention & control; risk; Risk assessment; Risk Factors; Selenium; Selenium - administration & dosage; Vegetables; Vegetables - chemistry; vitamin D; Vitamin D - administration & dosage; zeaxanthin
• ISSN: 1532-7914; 0163-5581; 1532-7914
• DOI: 10.1080/01635581.2013.795599

Mitogen-activated protein kinase (MAPK) pathways regulate cellular functions including cell proliferation, differentiation, migration, and apoptosis. Associations between genes in the DUSP, ERK1/2, JNK, and p38 MAPK-signaling pathways and dietary factors associated with growth factors, inflammation, and oxidative stress and risk of colon and rectal cancer were evaluated. Data include colon cases (n = 1555) and controls (n = 1956) and rectal cases (n = 754) and controls (n = 959). Statistically significant interactions were observed for the MAPK-signaling pathways after adjustment for multiple comparisons. DUSP genes interacted with carbohydrates, mutagen index, calories, calcium, vitamin D, lycopene, dietary fats, folic acid, and selenium. MAPK1, MAPK3, MAPK1, and RAF1 within the ERK1/2 MAPK-signaling pathway interacted with dietary fats and cruciferous vegetables. Within the JNK MAPK-signaling pathway, interactions between MAP3K7 and protein, vitamin C, iron, folic acid, carbohydrates, and cruciferous vegetables; MAP3K10 and folic acid; MAP3K9 and lutein/zeaxanthin; MAPK8 and calcium; MAP3K3 and calcium and lutein; MAP3K1 and cruciferous vegetables. Interaction within the p38-signaling pathway included MAPK14 with calories, carbohydrates saturated fat, selenium, vitamin C; MAP3K2 and carbohydrates, and folic acid. These data suggest that dietary factors involved in inflammation and oxidative stress interact with MAPK-signaling genes to alter risk of colorectal cancer.