The associations between migraine, unipolar psychiatric comorbidities, and stress-related disorders and the role of estrogen

Migraine is a common and often disabling neurovascular disorder. It has been linked with several psychiatric disorders, such as depression and anxiety, and to stress-related disorders, such as abuse and posttraumatic stress disorder (PTSD). Epidemiological data have consistently shown a higher preva...

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Bibliographic Details
Published in:Current pain and headache reports 2009-10, Vol.13 (5), p.404-412
Main Authors: Peterlin, B. Lee, Katsnelson, Michael J., Calhoun, Anne H.
Format: Article
Language:English
Subjects:
Comorbidity
Depressive Disorder - epidemiology
Depressive Disorder - physiopathology
Estrogens - physiology
Health risk assessment
Humans
Internal Medicine
Medicine
Medicine & Public Health
Mental disorders
Migraine
Migraine Disorders - epidemiology
Migraine Disorders - physiopathology
Pain Medicine
Post traumatic stress disorder
Stress Disorders, Post-Traumatic - epidemiology
Stress Disorders, Post-Traumatic - physiopathology
Stress, Psychological - epidemiology
Stress, Psychological - physiopathology
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Summary:Migraine is a common and often disabling neurovascular disorder. It has been linked with several psychiatric disorders, such as depression and anxiety, and to stress-related disorders, such as abuse and posttraumatic stress disorder (PTSD). Epidemiological data have consistently shown a higher prevalence of migraine, depression, anxiety, abuse, and PTSD in women as compared with men. The increased vulnerability of women to migraine and psychiatric disorders often occurs during periods of marked hormonal fluctuations of ovarian hormones. One consequence of these associations is the hypothesis that estrogens have a role in the pathophysiology of both disorders. This article offers an in-depth review of several studies linking psychiatric disorders and stress-related disorders with migraine. We also discuss the role of estrogen in the pathophysiologic overlap between these disorders. Finally, we briefly touch on where future research may be headed, in light of these data.
ISSN:1531-3433
1534-3081
DOI:10.1007/s11916-009-0066-1