The role of high mobility group box 1 (HMGB1) in colorectal cancer

HMGB1, the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. We studied the expression of HMGB1 and whether it is a prognostic factor...

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Bibliographic Details
Published in:Medical science monitor 2014-03, Vol.20, p.530-537
Main Authors: Süren, Dinç, Yıldırım, Mustafa, Demirpençe, Özlem, Kaya, Vildan, Alikanoğlu, Arsenal Sezgin, Bülbüller, Nurullah, Yıldız, Mustafa, Sezer, Cem
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Clinical Research
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Demography
Female
HMGB1 Protein - metabolism
Humans
Male
Middle Aged
Staining and Labeling
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Summary:HMGB1, the most important member of the high mobility group box protein family, is a nuclear protein with different functions in the cell; it has a role in cancer progression, angiogenesis, invasion, and metastasis development. We studied the expression of HMGB1 and whether it is a prognostic factor in colorectal carcinoma. The study included 110 cases that were histopathologically diagnosed with colorectal carcinoma from the tissue samples acquired by surgical resection and biopsy in Antalya Education and Research Hospital between 2008 and 2012. HMGB1 expression was examined via immunohistochemical method. HMGB1 expression was evaluated as negative in 32 (44.4%) of the patients and as positive in 40 (55.6%) patients. There was no relation between the HMGB1 expression and sex, age, tumor invasion depth, and histological type. However, a significant relation was detected between the HMGB1 expression and lymph node status, metastasis status, and stage (p:
ISSN:1643-3750
1234-1010
1643-3750
DOI:10.12659/msm.890531