Effect of Huanglian Jiedu Decoction on Thoracic Aorta Gene Expression in Spontaneous Hypertensive Rats

Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension effects of Huanglian Jiedu Decoction (HJD) on thoracic aorta gene expression in spontaneous hypertensive rats. Methods. A rat model of spontaneous hypertension was used. The gen...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Gao, Yi-Wen, Zhang, Zhuo, Xia, Meng, Zhuo, Shao-Yuan, Yue, Gui-Hua, Luo, Yuan
Format: Article
Language:English
Subjects:
Aorta
Aorta, Thoracic
Cardiovascular agents
Cardiovascular diseases
Care and treatment
Cell death
Chinese medicine
Comparative analysis
Coronary vessels
Cytokines
Data processing
DNA microarrays
Gene expression
Genes
Genetic aspects
Genomes
Health aspects
Herbs
Homeostasis
Hypertension
Immune system
Laboratory animals
Medical research
Medicine, Chinese
Medicine, Experimental
Muscle contraction
Muscles
Rats
Rodents
Smooth muscle
Spontaneous hypertension
Thorax
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Summary:Hypertension is one of the most common cardiovascular disorders with high mortality. Here we explored the antihypertension effects of Huanglian Jiedu Decoction (HJD) on thoracic aorta gene expression in spontaneous hypertensive rats. Methods. A rat model of spontaneous hypertension was used. The gene change profile of thoracic aorta after JHD treatment was assessed by GeneChip(GC) analysis using the Agilent Whole Rat Genome Oligo Microarray. Results. Hypertension induced 441 genes upregulated and 417 genes downregulated compared with the normal control group. Treatment of HJD resulted in 76 genes downregulated and 20 genes upregulated. GC data analysis showed that the majority of change genes were involved in immune system process, developmental process, and cell death. Conclusion. Hypertension altered expression of many genes that regulate various biological functions. HJD significantly reduced hypertension and altered the gene expression profiles of SHR rats. These changing genes were involved in many cellular functions such as regulating smooth muscle contraction, Ca(2+) homeostasis, and NO pathway. This study provides the potential novel insights into hypertension and antihypertension effects of HJD.
ISSN:1741-427X
1741-4288
DOI:10.1155/2014/565784