Diagnostic utility of serum and pleural levels of adenosine deaminase 1-2, and interferon-γ in the diagnosis of pleural tuberculosis

• Published in: Multidisciplinary respiratory medicine 2014-03, Vol.9 (1), p.12-12, Article 12
• Main Authors: Yurt, Sibel, Küçükergin, Canan, Yigitbas, Burcu Arpinar, Seçkin, Sule, Tigin, Hüseyin Cem, Koşar, Ayşe Filiz
• Format: Article
• Language: English
• Subjects: Original
• ISSN: 1828-695X; 2049-6958; 2049-6958
• DOI: 10.1186/2049-6958-9-12

To evaluate and compare the diagnostic efficiency of serum (s) and pleural (p) levels of adenosine deaminase (ADA)-1, ADA-2, total ADA, and interferon-gamma (IFN-γ) for the differential diagnosis of pleural tuberculosis (TB). Clinical and analytic data of 93 consecutive patients with pleural effusions from May 2012 to February 2013 were prospectively evaluated. The study population included 43 pleural TB, 23 malignancies, and 27 other exudates. The median and interquartile range of ADA-1, ADA-2, total ADA, and IFN-γ were evaluated according to their underlying diseases. There were no significant differences in sADA-1 and sIFN-γ values among each group. pADA-1, pADA-2, total pADA, and pIFN-γ levels were significantly higher in patients with pleural TB than in other patients (p