Clinical associations of serum interleukin-17 in systemic lupus erythematosus

Serum interleukin (IL)-17 concentrations have been reported to be increased in systemic lupus erythematosus (SLE), but associations with clinical characteristics are not well understood. We characterized clinical associations of serum IL-17 in SLE. We quantified IL-17 in serum samples from 98 SLE pa...

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Bibliographic Details
Published in:Arthritis research & therapy 2013-08, Vol.15 (4), p.R97-R97, Article R97
Main Authors: Vincent, Fabien B, Northcott, Melissa, Hoi, Alberta, Mackay, Fabienne, Morand, Eric F
Format: Article
Language:English
Subjects:
Adult
Autoimmunity
Computer software industry
Cross-Sectional Studies
Cytokines - blood
Development and progression
Enzyme-Linked Immunosorbent Assay
Female
Genetic aspects
Humans
Interleukin-17 - blood
Interleukin-17 - immunology
Interleukin-6 - blood
Interleukin-6 - immunology
Interleukins
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - immunology
Male
Medical research
Medicine, Experimental
Middle Aged
Physiological aspects
Severity of Illness Index
Systemic lupus erythematosus
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Summary:Serum interleukin (IL)-17 concentrations have been reported to be increased in systemic lupus erythematosus (SLE), but associations with clinical characteristics are not well understood. We characterized clinical associations of serum IL-17 in SLE. We quantified IL-17 in serum samples from 98 SLE patients studied cross-sectionally, and in 246 samples from 75 of these patients followed longitudinally over two years. Disease activity was recorded using the SLE Disease Activity Index (SLEDAI)-2k. Serum IL-6, migration inhibitory factor (MIF), and B cell activating factor of the tumour necrosis factor family (BAFF) were also measured in these samples. Serum IL-17 levels were significantly higher in SLE patients compared to healthy donors (P
ISSN:1478-6354
1478-6362
1478-6354
DOI:10.1186/ar4277