Blood Pressure, Internal Carotid Atery Flow Parameters and Age-Related White Matter Hyperintensities

White matter hyperintensities (WMH) are associated with hypertension. We examined interactions between blood pressure (BP), internal carotid artery (ICA) flow velocity parameters and WMH. We obtained BP measurements from 694 community-dwelling subjects at mean ages 69.6 (±0.8) and again at 72.6 (±0....

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 2014-01, Vol.63 (5), p.1011-1018
Main Authors: Aribisala, Benjamin S, Morris, Zoe, Eadie, Elizabeth, Thomas, Avril, Gow, Alan, Hernández, Maria C Valdés, Royle, Nataile A, Bastin, Mark E, Starr, John, Deary, Ian J, Wardlaw, Joanna M
Format: Article
Language:English
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Summary:White matter hyperintensities (WMH) are associated with hypertension. We examined interactions between blood pressure (BP), internal carotid artery (ICA) flow velocity parameters and WMH. We obtained BP measurements from 694 community-dwelling subjects at mean ages 69.6 (±0.8) and again at 72.6 (±0.7) years, plus brain MRI and ICA ultrasound at age 73±1 years. Diastolic and mean BP decreased and pulse pressure increased but systolic BP did not change between 70 and 73 years. Multiple linear regression, corrected for vascular disease and risk factors, showed that WMH at age 73 were associated with history of hypertension (β=0.13, p
ISSN:0194-911X
1524-4563
DOI:10.1161/HYPERTENSIONAHA.113.02735