Epigenetics and cancer metabolism

Highlights • Epigenetic modifications regulate cellular functions in health and disease, notably tumorigenesis. • Cancer cells are characterized by metabolic alterations that support their growth and survival. • Metabolic and epigenetic enzymes are often components of the same framework that sustain...

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Bibliographic Details
Published in:Cancer letters 2015-01, Vol.356 (2), p.309-314
Main Authors: Johnson, Christelle, Warmoes, Marc O, Shen, Xiling, Locasale, Jason W
Format: Article
Language:English
Subjects:
Amino acid metabolism
Cancer
Cell Proliferation
Citric Acid Cycle - physiology
DNA methylation
DNA Methylation - genetics
Energy Metabolism - genetics
Epigenesis, Genetic
Epigenetics
Glucose - metabolism
Glucose flux
Glycolysis - physiology
Hematology, Oncology and Palliative Medicine
Humans
Kinases
Metabolism
Metabolites
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - therapy
Protein Processing, Post-Translational - genetics
Tumor Microenvironment
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Summary:Highlights • Epigenetic modifications regulate cellular functions in health and disease, notably tumorigenesis. • Cancer cells are characterized by metabolic alterations that support their growth and survival. • Metabolic and epigenetic enzymes are often components of the same framework that sustains cancer development and progression. • Novel anti-cancer therapy focuses on intercepting metabolic networks and epigenetic reactions that promote tumorigenesis.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2013.09.043