The Association between the LPA Gene Polymorphism and Coronary Artery Disease in Chinese Han Population

Lp(a) has been well known as an independent risk factor for coronary artery disease (CAD). The LPA gene, as it encodes apo(a) of the Lp(a) lipoprotein particle, was associated with increased risk of CAD. The purpose of this study was to analyze the relationship between the polymorphisms of LPA gene...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-6
Main Authors: Song, Zi-Kai, Wu, Hai-Di, Cao, Hong-Yan, Qin, Ling
Format: Article
Language:English
Subjects:
Apolipoproteins
Base Sequence
Blood pressure
Cardiovascular disease
China - epidemiology
Cholesterol
Coronary Artery Disease - ethnology
Coronary Artery Disease - genetics
Coronary heart disease
Family medical history
Female
Gene loci
Genetic Association Studies
Genetic Markers - genetics
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Haplotypes
Heart attacks
Hepatology
Hospitals
Humans
Lipoprotein A
Lipoprotein(a) - genetics
Lipoproteins
Male
Middle Aged
Molecular Sequence Data
Mutation - genetics
Pathogenesis
Plasma
Polymorphism, Single Nucleotide - genetics
Population
Prevalence
Risk Factors
Studies
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Summary:Lp(a) has been well known as an independent risk factor for coronary artery disease (CAD). The LPA gene, as it encodes apo(a) of the Lp(a) lipoprotein particle, was associated with increased risk of CAD. The purpose of this study was to analyze the relationship between the polymorphisms of LPA gene and CAD in Chinese Han population. Five SNPs (rs1367211, rs3127596, rs6415085, rs9347438, and rs9364559) in the LPA gene were genotyped using Sequenom MassARRAY time-of-flight mass spectrometer (TOF) in 560 CAD patients as case group and 531 non-CAD subjects as control group. The numbers of these two groups were from Chinese Han ancestry. The results showed that allele (P=0.046) and genotype (P=0.026) of rs9364559 in the LPA gene was associated with CAD. The frequency of rs9364559 minor allele (G) in case group was obviously higher than that in control group. Results of haplotype analysis showed that 4 haplotypes which contained rs9364559-G were associated with increased risk of CAD in this population. This study explored rs9364559 in the LPA gene may be associated with the pathogenesis of CAD; and the risk of CAD might be higher in the population carrying 4 haplotypes of different blocks in the LPA gene.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/370670