Brain microvascular endothelial cells resist elongation due to curvature and shear stress

The highly specialized endothelial cells in brain capillaries are a key component of the blood-brain barrier, forming a network of tight junctions that almost completely block paracellular transport. In contrast to vascular endothelial cells in other organs, we show that brain microvascular endothel...

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Bibliographic Details
Published in:Scientific reports 2014-04, Vol.4 (1), p.4681-4681, Article 4681
Main Authors: Ye, Mao, Sanchez, Henry M., Hultz, Margot, Yang, Zhen, Bogorad, Max, Wong, Andrew D., Searson, Peter C.
Format: Article
Language:English
Subjects:
13/51
14/19
631/378/1341
631/61/350
Biological Transport
Blood-brain barrier
Blood-Brain Barrier - metabolism
Brain - blood supply
Capillaries
Cell junctions
Cell morphology
Cells, Cultured
Cytology
Elongation
Endothelial cells
Endothelial Cells - cytology
Endothelium, Vascular - cytology
Humanities and Social Sciences
Humans
Mechanical stimuli
Microvasculature
Microvessels - cytology
multidisciplinary
Nitric oxide
Science
Shear stress
Stress, Physiological
Tight junctions
Tight Junctions - metabolism
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Summary:The highly specialized endothelial cells in brain capillaries are a key component of the blood-brain barrier, forming a network of tight junctions that almost completely block paracellular transport. In contrast to vascular endothelial cells in other organs, we show that brain microvascular endothelial cells resist elongation in response to curvature and shear stress. Since the tight junction network is defined by endothelial cell morphology, these results suggest that there may be an evolutionary advantage to resisting elongation by minimizing the total length of cell-cell junctions per unit length of vessel.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep04681