Acute generalized exanthematous pustulosis induced by piroxicam: A case report

Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction characterized by an acute episode of sterile pustules over erythematous-edematous skin. The main triggering drugs are antibiotics, mainly beta-lactam and macrolides. Non-steroid anti-inflammatory drugs may rarel...

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Bibliographic Details
Published in:Indian journal of pharmacology 2014-03, Vol.46 (2), p.232-233
Main Authors: Cherif, Y, Jallouli, Moez, Mseddi, M, Turki, H, Bahloul, Z
Format: Article
Language:English
Subjects:
Acute Generalized Exanthematous Pustulosis - diagnosis
Acute Generalized Exanthematous Pustulosis - etiology
Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Biopsy
Causes of
Complications and side effects
Drug interactions
Drug therapy
Drug Watch
Female
Humans
Middle Aged
Pharmaceutical research
Pharmacology
Piroxicam
Piroxicam - administration & dosage
Piroxicam - adverse effects
Piroxicam - therapeutic use
Renal Colic - drug therapy
Side effects
Skin - drug effects
Skin - pathology
Skin diseases
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Description
Summary:Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction characterized by an acute episode of sterile pustules over erythematous-edematous skin. The main triggering drugs are antibiotics, mainly beta-lactam and macrolides. Non-steroid anti-inflammatory drugs may rarely be responsible. We describe a case of a woman with AGEP, who presented with generalized pustulosis lesions after the use of piroxicam for renal colic. The diagnosis was confirmed by the clinical and histological correlations and the dermatosis resolved after withdrawal of the drug.
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.129332