The horses are the first thought but one must not forget the zebras even if they are rare: Stiff person syndrome associated with malignant mesothelioma

Stiff person syndrome (SPS) is a rare condition that causes rigidity in the muscles of the body and extremities, difficulty in walking, episodic spasms and progressive disability. SPS is generally seen together with autoimmune disorders such as diabetes mellitus, thyroiditis, vitiligo and pernicious...

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Bibliographic Details
Published in:BMJ case reports 2014-04, Vol.2014, p.bcr2013203455
Main Authors: Koca, Irfan, Ucar, Mehmet, Kalender, Mehmet Emin, Alkan, Samet
Format: Article
Language:English
Subjects:
Abdomen
Acids
Asia
Autoimmune diseases
Breast cancer
Colorectal cancer
Diabetes
Family medical history
Female
Horses
Humans
Immunoglobulins
Lung Neoplasms - complications
Lung Neoplasms - diagnosis
Lymphoma
Mesothelioma
Mesothelioma - complications
Mesothelioma - diagnosis
Mesothelioma, Malignant
Middle Aged
Muscle pain
Neurological disorders
Other Asian
Parkinson's disease
Patients
Stiff-Person Syndrome - diagnosis
Stiff-Person Syndrome - etiology
Unusual Association of Diseases/Symptoms
Urine
Walking
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Summary:Stiff person syndrome (SPS) is a rare condition that causes rigidity in the muscles of the body and extremities, difficulty in walking, episodic spasms and progressive disability. SPS is generally seen together with autoimmune disorders such as diabetes mellitus, thyroiditis, vitiligo and pernicious anaemia. Rarely, it may develop as a paraneoplastic condition. SPS cases associated with breast cancer, small cell lung carcinoma, thymoma, Hodgkin's lymphoma and colorectal cancer have been reported in the literature. We present a case of a 58-year-old female patient who had malignant mesothelioma-associated SPS. Patients who have muscle spasms and difficulty in movement of joints should be evaluated for SPS before diagnosis of Parkinson's or other neurological disorders, and possible underlying malignancies should be excluded.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2013-203455