Bone marrow necrosis in an adult patient with precursor B-cell acute lymphoblastic leukaemia at the time of presentation

Non-haematological causes as sickle cell disease, infections as tuberculosis and toxic effects of chemotherapy such as interferon [alpha], granulocyte colony stimulating factor (G-CSF), all trans-retinoic acid (ATRA) and fludarabine. Rare causes of BMN are anorexia nervosa, haemolytic uraemic syndro...

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Bibliographic Details
Published in:BMJ case reports 2014-04, Vol.2014, p.bcr2014203891
Main Authors: Khoshnaw, Najmaddin S H, Muhealdeen, Dana Nasraldeen
Format: Article
Language:English
Subjects:
Biopsy
Bone marrow
Bone Marrow - pathology
Female
Gangrene
Granulocytes
Hematology
Humans
Images In
Middle Aged
Middle East
Mortality
Necrosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - complications
Precursor Cells, B-Lymphoid
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Summary:Non-haematological causes as sickle cell disease, infections as tuberculosis and toxic effects of chemotherapy such as interferon [alpha], granulocyte colony stimulating factor (G-CSF), all trans-retinoic acid (ATRA) and fludarabine. Rare causes of BMN are anorexia nervosa, haemolytic uraemic syndrome and antiphospholipid syndrome were reported. 1 2 Pathophysiology is unknown but could be due to marrow microvascular obstruction, cytokine release and T-cell and granulocyte activation. 1-3 So by early diagnosis and good supportive treatment the prognosis is promising unlike that mentioned in the literature.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2014-203891