Phage-displayed peptide libraries

Over the past year, significant advances have been achieved through the use of phage-displayed peptide libraries. A wide variety of bioactive molecules, including antibodies, receptors and enzymes, have selected high-affinity and/or highly-specific peptide ligands from a number of different types of...

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Bibliographic Details
Published in:Current opinion in biotechnology 1998-08, Vol.9 (4), p.427-436
Main Authors: Zwick, Michael B, Shen, Juqun, Scott, Jamie K
Format: Article
Language:English
Subjects:
Antibodies - metabolism
Bacteriophages - genetics
Bacteriophages - metabolism
Biotechnology - methods
Biotechnology - trends
Cross Reactions
Gene Library
Peptides - genetics
Peptides - immunology
Peptides - metabolism
Recombinant Proteins - genetics
Recombinant Proteins - metabolism
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Summary:Over the past year, significant advances have been achieved through the use of phage-displayed peptide libraries. A wide variety of bioactive molecules, including antibodies, receptors and enzymes, have selected high-affinity and/or highly-specific peptide ligands from a number of different types of peptide library. The demonstrated therapeutic potential of some of these peptides, as well as new insights into protein structure and function that peptide ligands have provided, highlight the progress made within this rapidly-expanding field.
ISSN:0958-1669
1879-0429
DOI:10.1016/S0958-1669(98)80017-7