The use of core needle biopsy as first-line in diagnosis of thyroid nodules reduces false negative and inconclusive data reported by fine-needle aspiration

The reported reliability of core needle biopsy (CNB) is high in assessing thyroid nodules after inconclusive fine-needle aspiration (FNA) attempts. However, first-line use of CNB for nodules considered at risk by ultrasonography (US) has yet to be studied. The aim of this study were: 1) to evaluate...

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Published in:World journal of surgical oncology 2014-03, Vol.12 (1), p.61-61, Article 61
Main Authors: Trimboli, Pierpaolo, Nasrollah, Naim, Guidobaldi, Leo, Taccogna, Silvia, Cicciarella Modica, Davide Domenico, Amendola, Stefano, Romanelli, Francesco, Lenzi, Andrea, Nigri, Giuseppe, Centanni, Marco, Giovanella, Luca, Valabrega, Stefano, Crescenzi, Anna
Format: Article
Language:English
Subjects:
Automation
Biopsy
Biopsy, Fine-Needle
Biopsy, Large-Core Needle
Cancer
Cellular biology
Diagnosis
False Negative Reactions
Female
Follow-Up Studies
Health aspects
Humans
Male
Medical research
Medicine, Experimental
Middle Aged
Patients
Prognosis
Statistical analysis
Thyroid cancer
Thyroid Gland - pathology
Thyroid Neoplasms - classification
Thyroid Neoplasms - diagnosis
Thyroid Nodule - diagnosis
Ultrasonography
Ultrasound imaging
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Summary:The reported reliability of core needle biopsy (CNB) is high in assessing thyroid nodules after inconclusive fine-needle aspiration (FNA) attempts. However, first-line use of CNB for nodules considered at risk by ultrasonography (US) has yet to be studied. The aim of this study were: 1) to evaluate the potential merit of using CNB first-line instead of conventional FNA in thyroid nodules with suspicious ultrasonographic features; 2) to compare CNB and FNA as a first-line diagnostic procedure in thyroid lesions at higher risk of cancer. Seventy-seven patients with a suspicious-appearing, recently discovered solid thyroid nodule were initially enrolled as study participants. No patients had undergone prior thyroid fine-needle aspiration/biopsy. Based on study design, all patients were proposed to undergo CNB as first-line diagnostic aspiration, while those patients refusing to do so underwent conventional FNA. Five patients refused the study, and a total of 31 and 41 thyroid nodules were subjected to CNB and FNA, respectively. At follow-up, the overall rate of malignancy was of 80% (CNB, 77%; FNA, 83%). However, the diagnostic accuracy of CNB (97%) was significantly (P 
ISSN:1477-7819
1477-7819
DOI:10.1186/1477-7819-12-61