Arachis hypogaea L. stem and leaf extract improves the sleep behavior of pentobarbital-treated rats

This study was conducted to evaluate the sedative effects of Arachis hypogaea L. stem and leaf extract (AHSLE) and determine its effect pathways through γ-aminobutyric acid (GABA)-gated channels on male Sprague-Dawley rats treated with pentobarbital. AHSLE was obtained from 98°C water (3 h, extracte...

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Bibliographic Details
Published in:Biomedical reports 2014-05, Vol.2 (3), p.388-391
Main Authors: ZU, XIAO-YAN, XIONG, GUANG-QUAN, GENG, SHENG-RONG, LIAO, TAO, LI, XIN, ZHANG, ZHEN-YA
Format: Article
Language:English
Subjects:
Arachis hypogaea L. stem and leaf extract
Care and treatment
Drugs
Experiments
Flumazenil
Health aspects
Insomnia
Laboratory animals
Latency
Leaves
Materia medica, Vegetable
Muscimol
Peanuts
Pentobarbital
Pentobarbital sodium
pentobarbital-treated rats
Physiology
Plant extracts
Rats
Rodents
Sleep
sleep behaviors
Sleep disorders
Sodium
Studies
γ-Aminobutyric acid
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Summary:This study was conducted to evaluate the sedative effects of Arachis hypogaea L. stem and leaf extract (AHSLE) and determine its effect pathways through γ-aminobutyric acid (GABA)-gated channels on male Sprague-Dawley rats treated with pentobarbital. AHSLE was obtained from 98°C water (3 h, extracted twice). AHSLE and flumazenil (a GABA type A receptor antagonist) were administered to the rats orally, whereas pentobarbital sodium and muscimol (a GABA type A receptor agonist) were administered intraperitoneally (i.p.). The results demonstrated that AHSLE decreased sleep latency and increased sleep time in pentobarbital-treated rats (50 mg/kg, i.p.). The coadministration of AHSLE and muscimol (0.05 mg/kg) significantly increased sleep time and reduced sleep latency in pentobarbital-treated rats and these actions were significantly antagonized by flumazenil at a dose of 3.5 mg/kg. These results indicated that AHSLE improved the sleep behavior in pentobarbital-treated rats, possibly through GABA-gated channel-related mechanisms.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2014.259